Abstract Objectives Examine trends in aggressive behavior from 1991 to 2015, investigate whether these apply equally all individuals, and explore the extent which differences over time cluster within families. Methods Our study included 69,465 measures 40,400 15,437 Dutch Aggression was measured between 1 4 times by self-report. We fitted a mixed effects model, modeling effect of time, age, gen...

Familial cancer clustering, without obvious heritability, poses a major challenge for current cancer risk assessment and management. Reliable determination of familial risks for cancer is important for clinical genetic counselling, but medically verified data on familial risks for many malignancies have been limited. However, the nationwide Swedish Family-Cancer Database allows a reliable chara...

OBJECTIVE To test the hypothesis that selected abnormalities cluster in type 2 diabetic families. Offspring of patients with type 2 diabetes have a 40-60% chance of developing type 2 diabetes and an increased frequency of impaired glucose tolerance (IGT) or unknown diabetes. These offspring also show metabolic abnormalities of type 2 diabetes, such as insulin resistance, high insulin and pro-in...

OBJECTIVES To assess the degree of relationship among individuals with hemangiomas and to evaluate the relative risk (RR) for family members of individuals with hemangiomas. DESIGN Retrospective case-control study. SETTING Utah Population Database. PARTICIPANTS Data sets of individuals of different ages with International Classification of Diseases, Ninth Revision (ICD-9) codes for hemang...

including Crohn’s disease (CD) and ulcerative colitis (UC), have been recognized for many years now to include a hereditary component. Familial occurrence in IBD is probably expected to be less frequent in Greece compared to Northern Europe and America [3]. According to retrospective studies, fi rst-degree familial clustering of IBD in the Mediterranean area, including Greece, seems to not exce...