نتایج جستجو برای: false positive reaction fpr
تعداد نتایج: 1080794 فیلتر نتایج به سال:
It is still challenging to identify rare functional DNA variants. Custom array-based resequencing has an advantage of processing hundreds of individuals at reasonable cost and has been used for medical sequencing studies with targeted genes. However, high false positive rate (FPR ∼3%) in detection of heterozygous signals limited the application of this technology. We have previously developed n...
BACKGROUND We previously found that a very low geno2pheno false positive rate (FPR ≤ 2%) defines a viral population associated with low CD4 cell count and the highest amount of X4-quasispecies. In this study, we aimed at evaluating whether FPR ≤ 2% might impact on the viro-immunological response in HIV-1 infected patients starting a first-line HAART. METHODS The analysis was performed on 305 ...
OBJECTIVE To estimate the accuracy of mammographic screening. DESIGN A meta-analysis of published literature. DATA SOURCES Published English-language randomized controlled trials, case-control studies, and demonstration projects involving screening mammography were identified using recent review articles. We found additional references using MEDLINE searches combining the MeSH terms "mammog...
NASA’s Kepler mission has provided several thousand transiting planet candidates during the four years of its nominal mission, yet only a small subset of these candidates have been confirmed as true planets. Therefore, the most fundamental question about these candidates is the fraction of bona fide planets. Estimating the rate of false positives of the overall Kepler sample is necessary to der...
Classification plays a critical role in false positive reduction (FPR) in lung nodule computer aided detection (CAD). The difficulty of FPR lies in the variation of the appearances of the nodules, and the imbalance distribution between the nodule and non-nodule class. Moreover, the presence of inherent complex structures in data distribution, such as within-class imbalance and high-dimensionali...
BACKGROUND AND AIMS Familial hypercholesterolaemia (FH) is an autosomal-dominant disease with frequency of 1/500 to 1/250 that leads to premature coronary heart disease. New approaches to identify FH mutation-carriers early are needed to prevent premature cardiac deaths. In a cross-sectional study of the Avon Longitudinal Study of Parents and Children (ALSPAC), we evaluated the biochemical thre...
OBJECTIVE To validate previously computed correction factors for free β-human chorionic gonadotrophin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies with hormone treatment and to determine the effect on false-positive rate (FPR). METHODS Retrospective study on 249 IVF and 250 ICSI cases and 20...
We sought to determine the potential effects of pooling on power, false positive rate (FPR), and bias of the estimated associations between hypothetical environmental exposures and dichotomous autism spectrum disorders (ASD) status. Simulated birth cohorts in which ASD outcome was assumed to have been ascertained with uncertainty were created. We investigated the impact on the power of the anal...
OBJECTIVE The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using. We evaluated the correlation between FPR obtained by V3 population-sequencing and the burden of CXCR4-using variants detected by V3 ultra-deep sequencing (UDPS) and Enhanced-Sensitivity Trofile assay (ESTA). METHODS 54...
INTRODUCTION The objective of this study was to evaluate the performance of first-trimester Down syndrome (DS) screening with serum sampling at different weeks of gestation. MATERIAL AND METHODS We studied 35,431 singleton pregnancies (2005-2011), including 145 DS cases. Screening performance was determined in different maternal age groups with serum sampling between weeks 9 + 0 and 13 + 6. ...
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