There is considerable evidence that transcription does not occur homogeneously or diffusely throughout the nucleus, but rather at a number of specialized, discrete sites termed transcription factories. The factories are composed of ~4-30 RNA polymerase molecules, and are associated with many other molecules involved in transcriptional activation and mRNA processing. Some data suggest that the p...

The basic structural elements of chromatin and chromosomes are reviewed. Then a model involving only three architectural motifs, nucleosomes, chromatin loops and transcription factories/chromomeres, is presented. Loops are tied through transcription factors and RNA polymerases to factories during interphase and to the remnants of those factories, chromomeres, during mitosis. On entry into mitos...

The evolution of B-Factories is discussed, and comments are made about the common features of present-day asymmetric storage ring collider designs. * Work supported by Department of Energy contract DE-AC03-76SF00515. Presented at the 4th International Symposium on Heavy E’lavour Physics, Orsay, France, June 25-29, 1991 There was a symposium Progress on B-Factories the day before the Heavy Flavo...

There is increasing evidence that different transcription units are transcribed together in discrete nuclear structures known as transcription factories. Various new techniques enable us to detect and characterize these structures. We review the latest findings and discuss how they support a model for transcription and chromosome organization.

background: anecdotal information has suggested that sodium benzoate is used with more than permissible doses during production steps of food products especially pickles and pickled cucumbers in food producing factories in markazi province and other food producing factories . the present study was done to evaluate factual concentration of sodium benzoate in these products. methods: in this stud...

A striking characteristic of Japanese factories is the extent of process control: from both the technical and the social viewpoint the labour and production system is controlled down to the very last detail. The characteristics of management and organization which underlie this are closely interwoven with Japanese culture. This explains why the work content. working conditions and working relat...

The position of genes in the interphase nucleus and their association with functional landmarks correlate with active and/or silent states of expression. Gene activation can induce chromatin looping from chromosome territories (CTs) and is thought to require de novo association with transcription factories. We identify two types of factory: "poised transcription factories," containing RNA polym...