factor v leiden deficiency is the most common hereditary hypercoagulable disease in the united states and involves 5% of the caucasian population. up to 30% of patients who present with deep vein thrombosis (dvt) or pulmonary thromboembolism present with this condition. this is a case report of a 36-year-old man who experienced one episode of dvt within the previous year and was admitted to our...

Background: Sickle cell disease occurs due to a mutation in β chains and the substitution of valine instead of glutamate in the sixth position of the ß-chain that causes polymerization and vascular blockage. The aim of this study was to compare the serum C, S proteins and factor V Leiden between sickle cell patients and the control group. Materials and Methods: In this case-control study, perf...

recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. it has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. thrombophilia is an important predisposition to blood clot formation and is cons...

normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. inherited alteration of factor v and prothrombin gene, the g20210a mutation, increases the resistance of factor v to degradation and booster production of prothrombin respectively. these alterations can increase hypercoagulability leading to thrombotic consequences. we aimed to assess the frequencies of ...

Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase the risk of the disease. Methods: This investigation was performed on blood samp...

background: sickle cell disease occurs due to a mutation in β chains and the substitution of valine instead of glutamate in the sixth position of the ß-chain that causes polymerization and vascular blockage. the aim of this study was to compare the serum c, s proteins and factor v leiden between sickle cell patients and the control group. materials and methods: in this case-control study, perfo...

OBJECTIVES To study the prevalence of factor V Leiden mutation in patients with chronic venous insufficiency and venous leg ulcers, compared with a control group, and to find out whether factor V Leiden mutation is more frequent in patients with chronic venous insufficiency and a history of deep venous thrombosis. DESIGN A case control study. SETTING Three outpatient dermatological clinics....