BACKGROUND DNA microarrays are now routinely used to monitor the transcript levels of thousands of genes simultaneously. However, the array fabrication method, hybridization conditions, and oligodeoxyribonucleotide probe length can impact the performance of a DNA microarray platform. RESULTS We demonstrate solution-phase hybridization behavior of probe:target interactions by showing a strong ...

AbstractIn Time Interleaved Analog to Digital (TIADC) conversion process, multi-mismatches can be occurred these mismatches highly degrade the system performance. Different mismatches can be frequency mismatches, offset mismatches, timing mismatches and gain mismatches. Due to different Hardware delays and it happens because TIADC ICs are not identical and goes worse when multiple chips are use...

BACKGROUND Epitope matching, which evaluates mismatched amino acids within antigen-antibody interaction sites (eplets), may better predict acute rejection than broad antigen matching alone. We aimed to determine the association between eplet mismatches and acute rejection in kidney transplant recipients. METHODS The association between eplet mismatches, broad antigen mismatches and acute reje...

Education-job mismatches are reported to have serious effects on wages and other labour market outcomes. Such results are often cited in support of assignment theory, but can also be explained by institutional and human capital models. To test the assignment explanation, we examine the relation between educational mismatches and skill mismatches. In line with earlier research, educational misma...

We propose a bio-inspired circuit performing pulse-density modulation with single-electron devices. The proposed circuit consists of three single-electron neuronal units, receiving the same input and are connected to a common output. The output is inhibitorily fedback to the three neuronal circuits through a capacitive coupling. The circuit performance was evaluated through Monte-Carlo based co...

The ability to detect biological analytes in a rapid, sensitive, operationally simple, and cost-effective manner will impact human health and safety. Hybrid biocatalyzed-carbon nanotube (CNT) nanowire-based detection methods offer a highly sensitive and specific platform for the fabrication of simple and effective conductometric devices. Here, we report a conductivity-based DNA detection method...

We propose a bio-inspired circuit performing pulse-density modulation with single-electron devices. The proposed circuit consists of three single-electron neuronal units, receiving the same input and are connected to a common output. The output is inhibitorily fedback to the three neuronal circuits through a capacitive coupling. The circuit performance was evaluated through Monte-Carlo based co...

Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine. The standard tools are optical-based sensors that are difficult to operate in low cost and to miniaturize for high-throughput measurement. Biosensors based on nanowire field-effect transistors have been developed...