نتایج جستجو برای: f35
تعداد نتایج: 128 فیلتر نتایج به سال:
We show that the fundamental group is not invariant under derived equivalence of smooth projective varieties. 2010 Mathematics Subject Classification. Primary 14-F05; Secondary 14-F35.
Heterozygous mutations in the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ATP-sensitive K(+) channel (K(ATP) channel), cause neonatal diabetes. To date, all mutations increase whole-cell K(ATP) channel currents by reducing channel inhibition by MgATP. Here, we provide functional characterization of two mutations (F35L and F35V) at residue F35 of Kir6.2, which lies within the NH(...
BACKGROUND Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both pathologies. Gene therapy may provide a successful approach to improve the clinical outcome of these conditions, but would benefit from the development o...
"Cell-in-cell" denotes an invasive phenotype in which one cell actively internalizes in another. The novel human T-cell line HOZOT, established from human umbilical cord blood, was shown to penetrate a variety of human cancer cells but not normal cells. Oncolytic viruses are emerging as biological therapies for human cancers; however, efficient viral delivery is limited by a lack of tumor-speci...
El objetivo principal de esta investigación fue evaluar el rendimiento en biomasa cuatro cultivares maíz. Realizada la Finca Aranda, Corregimiento Pocrí, Distrito Provincia los Santos, época lluvia. Para este fin, inicialmente, se realiza caracterización morfoclimática y estiman las curvas agresividad climática lluvia a través del índice modificado Fournier (IMF), ajustadas subcuenca río Purio....
OBJECTIVE Radiotherapy is an important and effective treatment method for non-small cell lung cancer (NSCLC). Nonetheless, radiotherapy can alter the expression of proangiogenic molecules and induce angiogenesis. Human apurinic/apyrimidinic endonuclease (APE1) is a multifunctional protein, which has DNA repair and redox function. Our previous studies indicated APE1 is also a crucial angiogenic ...
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated endonuclease Cas9 (Cas9) has high specificity to its target DNA as a gene editing tool. This characteristic makes it useful for detection. Combining the advantages of CRISPR/Cas9 and PCR, this study establishes novel CRISPR/Cas9-based detection method, named CRISPR/Cas9-typing PCR version 4.0 (ctPCR4.0). method...
Substantial spatial variability in the degradation rate of the phenyl-urea herbicide isoproturon (IPU) [3-(4-isopropylphenyl)-1,1-dimethylurea] has been shown to occur within agricultural fields, with implications for the longevity of the compound in the soil, and its movement to ground- and surface water. The microbial mechanisms underlying such spatial variability in degradation rate were inv...
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