Fig 1. Clinical extravasation 3 weeks after docetaxel infusion. INTRODUCTION Extravasation of chemotherapy is a rare devastating, cutaneous complication associated with administration of intravenous chemotherapy. Extravasation of chemotherapeutic agents can cause significant morbidity to already arduous chemotherapy regimens. Traditional treatment of extravasation is largely conservative in nat...

OBJECTIVES To evaluate the time and type of treatment following extravasation from intravenous infusion and the sequelae of the injuries. METHOD The charts of 12 patients who were referred to the Plastic and Orthopaedic Services at the University Hospital of the West Indies were reviewed. The study period was between May 2003 and January 2007. Data were collected on age, gender, site of extra...

Extravasations are common manifestations of iatrogenic injury that occur in patients requiring intravenous delivery of known vesicants. These injuries can contribute substantially to patient morbidity, cost of therapy, and length of stay. Many different mechanisms are behind the tissue damage during extravasation injuries. In general, extravasations consist of four different subtypes of tissue ...

BACKGROUND Infraorbital nerve constriction (IoNC) is an experimental model of trigeminal neuropathy. We investigated if IoNC is accompanied by dural extravasation and if botulinum toxin type A (BoNT/A) can reduce pain and dural extravasation in this model. METHODOLOGY/PRINCIPAL FINDINGS Rats which developed mechanical allodynia 14 days after the IoNC were injected with BoNT/A (3.5 U/kg) into ...

Purpose: To develop a new method to estimate contrast agent (CA) extravasation directly from the tissue residue function derived from dynamic susceptibility contrast (DSC) MR imaging and to compare the method to a published method for extravasation correction in patients diagnosed with intraaxial brain tumors. Background: CA extravasation is a confounding factor is DSC imaging of brain tumors s...

A male patient in his 20s presented at our clinic with pain caused by bone metastases of the primitive neuroectodermal tumor, and Sr-89 was administrated to palliate the pain. After receiving the injection, the patient complained of a slight burning pain at the catheterized area. Slight reddening and small circular swelling (diameter, 0.5 cm) were observed at the catheterized area. Sr-89 extrav...

We determined the effects of ibuprofen and methimazole on the formation of second- degree burn edema. Two small burns were produced on the back of rats. Ten minutes prior to burn, Evans blue ( EB) dye was injected through a femoral vein catheter. All animals were extravasation of evans blue. Ten groups of rats were studied. Immediately after induction of burns, test drugs were administered intr...