We report a case of a 75-year old man that came at hematologist’s attention for lymphoma evaluation due to axillary lymph node enlargement and fever. Thorax, abdomen and pelvis Contrast-Enhanced Computed Tomography (CECT) showed lymph nodes, spleen and liver lesions. Axillary lymph node biopsy was performed and the diagnosis of marginal zone lymphoma (MZL) at stage IV was postulated, then the p...

Extranodal NK/T-cell lymphoma is closely associated with Epstein-Barr virus (EBV) infection. However, the prognostic value of EBV-DNA in extranodal NK/T-cell lymphoma remains unclear. Thus, we conducted a meta-analysis to estimate its prognostic significance. PubMed, EMBASE, and Web of Science were used to search for studies conducted until June 12, 2017. The pooled hazard ratio (HR) and its 95...

Lymphoma may originate in extranodal sites. Extranodal lymphoma may also be secondary to and accompany nodal disease. Fluorine-18 fluorodeoxyglucose (18F-FDG) imaging has an essential role in the staging of lymphoma, in monitoring the response to therapy, and in detection of recurrence. The introduction of 18F-FDG PET/CT hybrid imaging allows for accurate localization of disease and may be spec...

To determine the significance of the t(2;5)(p23;q35) translocation in nodal and extranodal anaplastic large cell lymphoma (ALCL), we performed cytogenetic, molecular genetic, and immunohistochemical analyses of tumor tissues from 11 patients with CD30+ ALCL. Three of five patients with nodal ALCL had additional infiltration of the skin. Six patients had extranodal ALCL, two had primary intestin...

BACKGROUND AND PURPOSE The presence of extranodal spread in metastatic nodes significantly affects treatment planning and prognosis of the patient with head and neck cancer. We attempted to evaluate the predictive capability of MR imaging for the extranodal spread in the neck. MATERIALS AND METHODS We retrospectively studied MR images from 109 patients with histologically proved metastatic no...

BACKGROUND The presence and location of regional lymph node metastasis affect the prognosis of patients with thyroid cancer. Lymph node classification of the current TNM system may be inadequate because it insufficiently characterizes the nature and severity of lymph node metastasis that may influence prognosis. METHODS We retrospectively studied 240 patients with papillary thyroid cancer and...

Non-Hodgkin’s lymphoma (NHL) is the third most frequent malignant tumour in the head and neck, basocellular carcinoma of the skin and mucosal squamous cell carcinoma being the most frequent. Although nodal enlargement is the most common presentation in the head and neck, NHL may occur in extranodal locations. Two distinct extranodal sites are recognised: extranodal lymphatic locations or involv...

Approximately one-third of non-Hodgkin lymphomas (NHLs) arise primarily from sites other than lymph nodes, spleen or the bone marrow and even from sites which normally contain no native lymphoid tissue [1, 2]. Indeed, extranodal lymphomas can arise in almost every organ [1, 2]. However most of the presentations appears to be clustered in a few sites: skin, stomach, brain, small intestine and—wh...

UNLABELLED The aim of this study was to evaluate whether the maximum standardized uptake value (SUVmax) of (18)F-fluorodeoxyglucose (FDG) correlates with the International Prognostic Index (IPI) and the presence of extranodal involvement in patients with Diffuse Large B-Cell Lymphoma (DLBCL). MATERIAL AND METHODS 77 patients (age: 57.2±18.5, 40F, 37M) with DLBCL who underwent FDG PET/CT for i...

PRACTICAL RELEVANCE The majority of feline lymphoma is extranodal. While the gastrointestinal (GI) tract is the most commonly affected site, non-GI extranodal lymphomas, which are the focus of this review, account for a large proportion of lymphomas in cats. This article discusses prognostic factors for the most common of these extranodal lymphomas, both in general terms and specifically for in...