We report a case of an extragonadal germ cell tumor in the retrovesical region. The patient complained of a perineal and micturition pain. Urethrography, CT and MRI showed a retrovesical tumor protruding into the bladder. Alfa-fetoprotein was increased to 12,170 ng/ml. Bilateral testes did not contain any palpable mass by careful palpation. No tumor was detected by ultrasonography, either. Clin...

Germ cell tumors (GCTs) in males predominantly arise from testicular tissue, but 2e5% arise in extragonadal sites with no evidence of a primary testicular tumor, thus called extragonadal germ cell tumors (EGCTs). They mostly arise in the mid-axis of the body; 50e70% in the mediastinum, 30e40% in the retroperitoneal space, and fewer arise in the pineal gland and the suprasellar region. Few occur...

Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]....

OBJECTIVE To review the role of circulating C(19) steroids as precursors of estrogens in postmenopausal women. DESIGN Review of current published literature. RESULT(S) In postmenopausal women as in men, estradiol no longer functions as a circulating hormone, because it ceases to be formed by the ovaries at the time of menopause. Estradiol continues to be formed in a number of extragonadal s...

Between 2 and 5% of malignant germ cell tumors in males arise at extragonadal sites. The origin of extragonadal retroperitoneal germ cell tumors remains controversial. Whether these develop primarily in the retroperitoneum or are metastases of a primary testicular tumor has long been debated. We report a 38-year-old male who presented with abdominal pain and was diagnosed with retroperitoneal s...

Two malignant extragonadal germ cell tumors are reported, histologically classified as immature teratomas, having pseudodiploid karyotypes with complex structural rearrangements but lacking isochromosome 12p or other rearrangements involving 12p. The absence of 12p material in structural rearrangements was confirmed by chromosome painting. In the two tumors the following common chromosomal brea...

A huge retroperitoneal tumor with a right orbital mass was detected and proved to be an extragonadal nonseminomatous germ cell tumor on biopsy. BEP chemotherapy caused some regression in orbital mass however no change in retroperitoneal tumor size as well as serum tumor marker levels occurred. Herein, we present a rarely seen entity of extragonadal retroperitoneal nonseminomatous germ cell tumo...

Malignant extragonadal germ cell tumors can arise anywhere along the gonadal ridge. Locations may include the retroperitoneal, mediastinum, presacral region, and pineal gland [1]. An Extragonadal Germ Cell Tumor (EGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads [2]. EGCT arise from primordial germ cel...

Neoplasms from germ cell origin are a heterogeneous group of tumors rarely seen in the pediatric population, teratoma is the most frequent among them. They can occur in either gonadal or extragonadal locations. Extragonadal teratoma arising from abdominal viscera is very unusual. There are less than a hundred reported cases of gastric teratoma in the worldwide literature. Since the occurrence o...

BACKGROUND Extragonadal localization of germ cell tumors (GCTs) is rare; to the best of our knowledge, a location in the soft tissue of the arm has never been previously reported in the literature. CASE PRESENTATION We report the case of a 37-year-old man who presented with a primary malignant mixed non-seminomatous GCT (teratocarcinoma variety) in the right arm, treated by a combination of c...