AIM To describe a situation in which an opioid-dependent patient overcame naltrexone blockade. DESIGN, CASE REPORT, SETTING: Addiction treatment center in St Petersburg, Russia. PARTICIPANT Patient with naltrexone implant. INTERVENTION Detoxification. MEASUREMENTS Clinical observations. CONCLUSIONS It is possible, but very difficult, to overcome naltrexone blockade by using large doses ...

The U.S. Army has a need for continuous, accurate estimates of the wet bulb globe temperature to protect soldiers and civilian workers from heat-related injuries, including those involved in the storage and destruction of aging chemical munitions at depots across the United States. At these depots, workers must don protective clothing that increases their risk of heat-related injury. Because of...

ID: I935 Timothy W. Duket and Seokcheon Lee School of Industrial Engineering, Purdue University West Lafayette, IN 47906

We study plasmonic waveguides with dielectric cores and hyperbolic multilayer claddings. The proposed design provides better performance in terms of propagation length and mode confinement in comparison to conventional designs, such as metal-insulator-metal and insulator-metal-insulator plasmonic waveguides. We show that the proposed structures support long-range surface plasmon modes, which ex...

In logistics networks involving one supply point (depot) and several geographically dispersed demand points (e.g., retail stores), delivery shortages will result if the design of delivery routes ignores random period-to-period ̄uctuations in customer demands. Delivery shortages may be costly enough for the depot to seek strategies to prevent them. A requirement for rational comparison of strate...

The CNGS project was approved by CERN Council in December 1999. This report gives a short description of the νμ beam to be built at CERN in the direction of the INFN Gran Sasso underground laboratory (LNGS). The first goal of this new facility is the production of sufficient νμ in an energy region optimised for the detection of an adequate number of ντ produced by oscillation at LNGS. The layou...

OBJECTIVES In a cluster randomised controlled trial, offering financial incentives improved adherence to antipsychotic depot medication over a 1-year period. Yet, it is unknown whether this positive effect is sustained once the incentives stop. METHODS AND ANALYSES Patients in the intervention and control group were followed up for 2 years after the intervention. Primary and secondary outcome...

The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder us...