Background MicroRNAs (miRNAs) are implicated in various biological processes including anticoagulation. However, the modulation of miRNA by pharmacological intervention such as warfarin treatment in patients receiving warfarin has not been disclosed yet. The aim of this study work was to assess the effect of warfarin drug on expression level of mir-133a-3p in patients with mechanical heart valv...

Achieving an effective treatment of cancer is difficult, particularly when resistance to conventional chemotherapy is developed. P-glycoprotein (P-gp) activity governs multi-drug resistance (MDR) development in different cancer cell types. Identification of anti-cancer agents with the potential to kill cancer cells and at the same time inhibit MDR is important to intensify the search for novel ...

Abstract Background In China, during the cultivation process of Pleurotus ostreatus , yield and quality fruiting bodies are easily affected by high temperatures in summer. Nitric oxide (NO) plays an important regulatory role response to abiotic stress, previous studies have found that NO can induce alternative oxidase ( aox ) experssion heat stress (HS) regulating aconitase. However, pathway is...

Contact lens wear is a successful form of vision correction. However, adverse responses can occur during wear. Many of these adverse responses are produced as a consequence of bacterial colonization of the lens. The present study demonstrated that during asymptomatic contact lens wear lenses are colonized by low levels of bacteria with gram-positive bacteria, such as coagulase negative staphylo...

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Background: Infertility is a problem for 15 to 30% couples. Male infertility may be a result of insufficient number of sperms and poor motility. Spermatozoon consists of a head,midpiece and tail. The long tail consist micro-tubules that from part of the propulsion system of the spermatozoon. Motility of sperm is the result of relation between ATP,micro-tubules and dynein. Depression is one of t...

Brucellosis is a debilitative disease that imposes costs on both economy and society. It is shown that although the vaccine can prevent abortion, it does not provide complete protection against infection. In Iran, Brucella melitensis is a common causative agent for brucellosis and BP26 protein of this bacterium having a good antigenesity and an important vaccine candidate. In this study B. meli...