Male rabbits received Z-thyroxine (250 /xg/kg) subcutaneously for 7 days and exhibited marked tachycardia, elevation of protein-bound iodine levels and a 26$ mean weight loss. Their hearts were isolated and perfused by die Langendorff technique. In 8 thyroid-treated rabbits the mean heart rate before they were killed and also after 30 minutes of perfusion was much higher than that of 10 control...

The pyruvate dehydrogenase kinases (PDK1-4) regulate glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC). Immunoblot analysis with antibodies raised against recombinant PDK isoforms demonstrated changes in PDK isoform expression in response to experimental hyperthyroidism (100 microg/100 g body weight; 3 days) that was selective for fast-twitch vs sl...

OBJECTIVE Thyroid hormones regulate energy metabolism and act on the mitochondria, which is an important source of free radicals in the cell. Reactive oxygen types play a significant role in physiological mechanisms, but in excessive amounts they can cause oxidative damage in molecules. The aim of the present study was to determine levels of lipid peroxidation caused by induced hyperthyroidism ...

This work analyzes the effects of Satureja khuzestanica essential oil (SKEO) on the thyroid and antioxidant system, assessed by measuring levels of tri-iodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), reduced glutathione (GSH), and glutathione peroxidase (GPx) activity. Forty adult male Sprague Dawley rats (225 ± 25 g) were divided into five...

Structural and functional derangement of the liver has been noted in patients with hyperthyroidism(Cameron and Kurunaratne, 1935;Lichtman, 1953;Werner, 1955). Paul, in 1865, was the first to mention the association of hepatic cirrhosis and toxic thyroid disease. Jaundice was first mentioned by Haberson(1874). Kerr and Rusk, in 1922, reported acute yellow atrophy of the liver associated with hyp...