Suppose G is a graph, r is a positive real number and S(r) is a circle of perimeter r. For a positive real number t ≤ r, a (t, r)circular consecutive colour-list assignment L is a mapping that assigns to each vertex v of G an interval L(v) of S(r) of length t. A circular L-colouring of G is a mapping f : V (G) → S(r) such that for each vertex v, f(v) ∈ L(v) and for each edge uv, the distance be...

BACKGROUND Frequent ventilator circuit changes are expensive and sometimes unnecessary. Following the worldwide trend to lengthen the intervals for ventilator circuit change from 2 days to 1 week, this study aims to assure that low rate of ventilator-associated pneumonia (VAP) can be maintained with cost containment. METHODS Ventilator circuits were routinely changed every 7 days in the study...

Background: Maintenance treatment of schizophrenia reduces relapse rates of this disease. This treatment is carried out for long periods of time and occasionally for lifelong. Dose reduction strategies are designed to maintain the benefits of antipsychotic drug therapy, while reducing the side effects. The authors tested a new dose reduction approach by increasing the interval between administr...

OBJECTIVE Dose reduction strategies for the maintenance treatment of schizophrenia are designed to maintain the benefits of antipsychotic drug therapy while reducing risks. Previous strategies with decanoate preparations have been based on the use of lower doses per injection to achieve dose reduction; these strategies have achieved dose reduction but have resulted in some increase in symptoms....