Aloe products are one of the top selling health-functional foods in Korea, however the adequate level of intake to achieve desirable effects are not well understood. The objective of this study was to determine the intestinal uptake and metabolism of physiologically active aloe components using in vitro intestinal absorption model. The Caco-2 cell monolayer and the everted gut sac were incubate...

The rats were fasted overnight and then anesthetized with pentobarbiturate. Segments of the duodenum, jejunum, ileum, and colon of 6 cm length were isolated. Each specimen was everted to prepare a sac with mucosa on the outside. Each gut sac was filled with 600μl of multitracer solution and then immersed in 10ml of the buffer solution and incubated with bubbling 95% O2 and 5% CO2 at 37 ◦C for 9...

AIMS/BACKGROUND This study was evaluated synergistic effect of a polyherbal formulation (PHF) of Allium sativum L., Eugenia jambolana Lam., Momordica charantia L., Ocimum sanctum Linn., and Psidium guajava L. on p-glycoprotein (Pgp) of intestine. These five herbs were traditionally used for diabetes. These herbs are commonly present in Ayurvedic product as antidiabetics in India. MATERIALS AN...

Objectives: The objective of this study is to extract Phytochemical constituent from Cinnamon Bark and design develop the transdermal patch herbal drug along with modern medicine Glibenclamide using solvent casting method reduce dose required obtain same pharmacological effect, also toxicity drug. Methods: Transdermal patches were formulated by method. physical chemical similarity medication ba...

To investigate the intestinal absorption of a fibrinolytic and proteolytic lumbrokinase extracted from Eisenia andrei, we used rat everted gut sacs and an in situ closed-loop recirculation method. We extracted lumbrokinase from Eisenia andrei, and then raised polyclonal antibody against lumbrokinase. Fibrinolytic activity and proteolytic activity in the serosal side of rat everted gut sacs incu...

Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...