The solvent induced polymorphism observed in a cyclometalated iridium(iii) ethylenediamine ionic complex is a new tool to modulate and enhance emission in the solid crystalline state.

New chemotherapeutics are urgently needed to combat malaria. We previously reported on a novel series of antimalarial, ethylenediamine-based inhibitors of protein farnesyltransferase (PFT). In the current study, we designed and synthesized a series of second generation inhibitors, wherein the core ethylenediamine scaffold was varied in order to examine both the homology model of Plasmodium falc...

Intravenous aminophylline is used as a first line treatment for bronchial asthma. This preparation consists of theophylline or a salt of theophylline dissolved in a solution of ethylenediamine, which confers greater solubility and reduces the alkalinity of the drug.1 In clinical usage side effects of tachycardia, seizures and nausea are well known. We report on the much less common, but clinica...

Three types of copper sulfides including CuS, Cu7S4 and Cu9S5 were successfully synthesized at different concentrations of ethylenediamine in a liquid phase synthesis process. The whole shape evolution of Cu7S4 microstructures could be manipulated by adjusting the concentration of ethylenediamine. This study indicates that the coordination chemistry of ethylenediamine ligands and copper cations...

Two new compounds containing the title diphosphono-polyoxometalate anion and diprotonated ethylenediamine (enH(2)) or piperazine (ppzH(2)) countercations have been hydrothermally synthesized and structurally characterized ((enH(2))(4)[Mo(7)O(16)(O(3)PCH(2)PO(3))(3)].7H(2)O, triclinic, P(-)1, Z = 2, a = 10.3455(7) A, b = 13.136(1) A, and c = 20.216(3) A, alpha = 93.247(6) degrees, beta = 96.434(...

Zn(2+)-induced fluorescence enhancement of the TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine)-based ligand, N,N-bis(1-isoquinolylmethyl)-N',N'-bis(pyridylmethyl)ethylenediamine (N,N-1-isoBQBPEN, 1b), has been investigated. Upon Zn(2+) binding, 1b shows a fluorescence increase (ϕZn = 0.028) at 353 and 475 nm. The fluorescence enhancement at longer wavelengths is due to intramolecular ...

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay....

BACKGROUND Compounds containing ethylenediamine (-NCH2CH2N-) moiety are known to exhibit antimicrobial, -fungal, -bacterial, -tuberculosis and -cancer activities. MATERIALS AND METHODS In the present study, we evaluated the in vitro cytotoxic activity of N,N'-bis(2-hydroxybenzyl)- (6), N,N'-bis(5-bromo-2-hydroxybenzyl)- (7) and N,N'-bis(5-chloro-2-hydroxybenzyl) (8)- ethylenediamine dihydroch...