We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. ADAM17 protein expression in 50 cases with...

human papillomavirus (hpv) dna has been identified in esophageal carcinomas. however, the incidence of hpv varies significantly in different geographical locations. in this study, neoplasms from turkmen sahra, a region in golestan province in northeast part of iran, with a high incidence of squamous cell carcinoma were analyzed for the presence of hpv dna. turkmen sahra is located in the cancer...

Background: Esophageal carcinoma is one of the most lethal gastrointestinal (GI) malignant tumors worldwide.  The disease is known to have a high incidence in northern Iran; however, its condition in the South is not much clear. Objective: In this retrospective study we investigated the epidemiology and time trends of esophageal carcinoma in Fars Province, South of Iran. Methods: In a retrospec...

Esophageal squamous cell carcinoma and esophageal adenocarcinoma are cancers of high mortality. EAC develops through Barrett's esophagus (BE) and columnar dysplasia, preceded by gastro-esophageal reflux disease. The risk of esophageal squamous cell carcinoma is increased by smoking and alcohol consumption. New treatment options for esophageal cancer are desperately needed. Toll-like receptors (...

abstract background: esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. this may be due to increasing rates of barrett’s esophagus, gastroesophageal reflux, smoking and obesity. this study was performed from 1991 to 2005 in order to evaluate variou...

telomerase activation is one of the main pathways to immortalize cancer cells. in many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits...

most patients with gastrointestinal cancers refer to the health centers at advanced stages of the disease and conventional treatments are not significantly effective for these patients. therefore, using modern therapeutic approaches with lower toxicity bring higher chance for successful treatment and reduced adverse effects in such patients. the aim of this study is to evaluate the effect of av...

BACKGROUND Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 in esophageal squamous cell carcinoma and adjacent non-transformed squamous epithelium of the esophagus, as well as in control biopsy samples from esophageal squamous epith...

High levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in esophageal squamous carcinoma. C-C chemokine receptor type 7 (CCR7) is overexpressed in multiple tumor types and has been suggested to act as an oncogene and pro-angiogenic factor. This study aimed to elucidate the effect of CCR7 on the angiogenic capacity of esophageal squamous carcinoma cells in ...

malignant tumors of pancreas are usually primary neoplasms and pancreatic metastases are rare findings. we are reporting a case of squamous cell carcinoma (scc) of the esophagus with pancreatic metastasis. a 59-year old woman was admitted with chief complaint of abdominal pain and mass. she was a known case of esophageal scc since 4 years before when she had undergone transthoracic esophagectom...