نتایج جستجو برای: erythromelalgia
تعداد نتایج: 422 فیلتر نتایج به سال:
Erythromelalgia is characterized by intense burning pain, erythema, and heat in affected areas after precipitating factors such as warm temperature or stress. It is refractory to treatment in some situations. We describe a woman with adenosquamous cell carcinoma of the lung and medically refractory erythromelalgia. The symptoms of erythromelalgia presented as refractory to any medical treatment...
OBJECTIVE Mutations in SCN9A have been reported in (1) congenital insensitivity to pain (CIP); (2) primary erythromelalgia; (3) paroxysmal extreme pain disorder; (4) febrile seizures and recently (5) small fibre sensory neuropathy. We sought to investigate for SCN9A mutations in a clinically well-characterised cohort of patients with CIP and erythromelalgia. METHODS We sequenced all exons of ...
Erythromelalgia is a painful disorder of the extremities characterized by redness, swelling, a burning sensation, and an increase in skin temperature exacerbated by exposure to heat. 1 An early description was reported by Mitchell 2 in 1878. He coined the term erythromelalgia to denote the clinical features of redness (erythros), involvement of the extremities (melos), and the symptom of pain (...
This case report examines the presentation of a patient with erythromelalgia that was misdiagnosed as cellulitis on several prior occasions. The presentation of bilateral acral edema and erythema, especially in the setting of myeloproliferative and/or connective tissue diseases, should alert the physician to the possibility of alternate diagnoses, including erythromelalgia. Treatments target sy...
Erythromelalgia is a clinical diagnosis characterized by erythema, increased temperature and burning pain in acral skin. The pain is relieved by cooling and aggravated by warming. The symptoms have been hypothesized to be caused by skin hypoxia due to increased arteriovenous shunting. We examined skin microvascular perfusion in response to vasoconstrictory and vasodilatory stimuli, to character...
Erythromelalgia is characterized by intermittent heat, redness, and pain affecting the extremities.1 Exercise and increase in temperature are precipitating factors. During symptoms, blood flow and temperature increase without a concomitant increase in oxygenation.2 Severe sudomotor impairment and evidence of peripheral adrenergic dysfunction are also present.2 A recent study showed that a predo...
Sir, There was an epidemic of erythromelalgia among secondary school students in Hubei, China, in February and March, 1987. Among five schools the average prevalence was 12 (6.4% for males, 28.6% for females; 13.5% for boarders, 22 % for non-resident students). The disease was characterized by burning pain in the toes and soles of the feet and redness, congestion, and edema of the foot; a few p...
Gain-of-function missense mutations of voltage-gated sodium channel Na(V)1.7 have been linked to the painful disorder inherited erythromelalgia. These mutations hyperpolarize activation, slow deactivation and enhance currents evoked by slow ramp stimuli (ramp currents). A correlation has recently been suggested between the age of onset of inherited erythromelalgia and the extent of hyperpolariz...
Erythromelalgia is a rare disorder frequently associated with myeloproliferative disorders. We describe a case of elderly patient diagnosed with myeloproliferative disorder in remission. The patient was on aspirin for secondary prevention of stroke and was taken off aspirin and developed erythromelalgia within two weeks of withdrawal of aspirin. After restarting aspirin, patient's symptoms impr...
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