There are several syndromes in which an erythriblastic reaction, comparable with the granulocytic reaction of granulocytic leukaemia, is prominent. One is the "leukanaemia" of von Leube (1900) defined by Foy, Kondi, and Murray (1946) as " a haematological condition in which there co-exist a pernicious anaemia-like and a leukaemia-like blood picture with corresponding marrow disorder of the eryt...

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic beta-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylene-bisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes ...

We investigated the effects of phorbol ester (phorbol 12-myristate 13-acetate; PMA) treatment on the adhesive behaviour of three erythroleukaemia cell lines: HEL, LAMA-84 and AP217. In the three cell lines PMA induced an increase in expression of a megakaryocytic marker: alpha IIb beta 3 integrin, but did not promote activation of this receptor. Indeed, an antibody specific for the activated fo...

AIMS Classic erythroleukaemia (acute myeloid leukaemia M6, or M6 AML) is defined as an excess of myeloblasts in an erythroid predominant background. Leukaemia variants in which the primitive blast cells are demonstrably erythroid are extremely rare and poorly characterised. Variably referred to as "true erythroleukaemia" or "acute erythremic myelosis", they are often included within the M6 AML ...

BACKGROUND AND OBJECTIVES The human erythroleukaemia (HEL) cell line has a highly rearranged genome. We matched whole chromosome analysis with cytogenomic microarray data to build a detailed description of these rearrangements. METHODOLOGY We used a combination of single nucleotide polymorphism array and multiple fluorescence in situ hybridization approaches, and compared our array data with ...

-The effect of exogenous and endogenous prostaglandins on the patterns of growth and differentiation of Friend erythroleukaemia cells (FLC) were studied. During the differentiation process, DMSO stimulated PGE synthesis by an average of 95o%. The addition of a long-acting synthetic analogue of PGE2, 16,16-dimethylPGE2-methyl ester (di-M-PGE2) to the culture medium only slightly and temporarily ...

Case report A 67-year-old man presented in May 1978 with malaise and splenomegaly. Initial blood count showed haemoglobin 12-1 g/dl, total white cell count 25 7 x 10'/1 (polymorphs 5 %, lymphocytes 93 %, eosinophils 2 %), platelet count 98 x 10'/1. Bone marrow examination showed a 66% infiltration by mature lymphocytes. Haematopoiesis otherwise was morphologically normal. A diagnosis of chronic...

AIMS To evaluate the incidence and outcome of acute myeloid leukaemia (AML), FAB M6 (erythroleukaemia). METHODS A demographic study in the Northern Health Region of England between 1983 and 1999. RESULTS Thirty three cases were diagnosed and registered prospectively. The overall incidence was 0.077 cases/100,000/year. There was a pronounced rise in incidence in patients aged 56 years or mor...