The present study was carried out to evaluate the antioxidant and free radical scavenging activity of methanolic extract of Ervatamia coronaria leaves (Apocynaceae) in various systems. DPPH radical, superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the extract. The antioxidant activity of methanolic ex...

Ervatamia coronaria (Apocynaceae) is a glabrous, evergreen tree commonly grown in the gardens of West Pakistan. A number of indole alkaloids have previously been reported from this plant [1-8]. Two of these, possessing a tetracyclic structure, are voaphylline (I) and hecubine (II). We report here the C-13 NMR of hecubine and voaphylline as well as a study of the mass spectral fragmentation patt...

a 48-year-old woman was admitted to the emergency department with complaints of typical chest pain, cold sweat, and dyspnea of 24 hours’ duration. she had a history of hypertension, hyperlipidemia, and diabetes mellitus for many years. on admission, her electrocardiogram (ecg) revealed normal sinus rhythm and dynamic t inversion in the precordial leads. her enzyme levels were normal. transthora...

coronary-cameral fistulas (ccfs) constitute a rare anomaly that can be incidentally detected during angiography. ccfs are solitary, large or small assemblies that originate from coronary arteries and enter one of the cardiac chambers. we describe a 29-year-old woman, who referred to our clinic with the chief complaints of palpitation, atypical chest pain, and dyspnea on exertion (functional cla...

Conophylline (CnP), a vinca alkaloid extracted from the leaves of the tropical plant Ervatamia microphylla, attenuates hepatic fibrosis in mice. However, little is known about whether CnP inhibits steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) in mice. A methionine-choline-deficient (MCD) diet was administered to male db/db mice as a NASH model, and CnP (1 μg/kg/d...

Ervatamins (A, B and C) are papain-like cysteine proteases from the plant Ervatamia coronaria. Among Ervatamins, Ervatamin-C is a thermostable protease, but it shows lower catalytic efficiency. In contrast, Ervatamin-A which has a high amino acid sequence identity (∼90%) and structural homology (Cα rmsd 0.4 Å) with Ervatamin-C, has much higher catalytic efficiency (∼57 times). From the structur...

conclusions routine predilation of the sb in provisional stenting of true bifurcation lesions seems to be ineffective and might be associated with some undesirable consequences. still, there are some complex ostial lesions of the sb which could benefit from predilation. patients and methods sixty patients with true bifurcation lesions according to the medina classification were included in the ...

A phytochemical survey for alkaloid-containing plants has been conducted in South Sumatra including traditional medicinal plants. During the 180 satisfactory herbarium sample were obtained and all of them tested alkaloids. The results showed that 33 species gave a positive test alkaloids, high alkaloid contents shown by: Alstonia scholaris, angustiloba, Ervatamia coronariaa, Voacanga foetida Bl...