The toxicokinetics of ergovaline (an ergopeptine mycotoxin present in some grasses infected with endophytic fungus of the genus Neotyphodium) were studied after intravenous administration of a single dose of 15 microg/kg bwt in four gelding horses. Plasma ergovaline concentrations were measured by high performance liquid chromatography, and the kinetic data were described by a three-compartment...

Tall fescue (Schedonorus arundinaceus (Shreb.) Dumort) is a cool-season forage grown in the mid-south United States of America that has potential for spring silage. Ergovaline produced by fungal endophyte Neotyphodium coenophialum preserved tall silage and can induce toxicosis livestock. Condensed tannins, such as quebracho (Schinopsis quebracho-colorado (Schltdl.) F.A. Barkley T. Meyer) extrac...

Pharmacologic profiling of serotonin (5HT) receptors of bovine lateral saphenous vein has shown that cattle grazing endophyte-infected (Neotyphodium coenophialum) tall fescue (Lolium arundinaceum) have altered responses to ergovaline, 5HT, 5HT2A, and 5HT7 agonists. To determine if 5HT receptor activity of tall fescue alkaloids is affected by grazing endophyte-free (EF), wild-type [Kentucky-31 (...

Endophyte (Acremonium cotnophiaJum Morgan-Jones et Gams) -Infected tall fescue (Festuca arundinacea Schreb.) produces ergopeptiDe alkaloids (EP) that may be associated with fescue toxicosis symptoms in cattle (B03 taurus). A study was conducted during 1983 and 1984 at Watkinsville, GA, to determine the effects of endophyte infection, season, and N fertilization on EP concentration and Steer ave...

Tannins may bind to alkaloids in endophyte-infected (E+) tall fescue and attenuate fescue toxicosis. To test this hypothesis, thirty-two 4-mo-old lambs were randomly assigned to 4 treatments (8 lambs/treatment) in a 2 by 2 factorial design that included a basal diet of tall fescue hay [E+ or endophyte-free (E-)] supplemented with (TS) or without (CS) bioactive Quebracho tannins. The concentrati...

AIM To determine the amount of ergovaline and lysergic acid retained or excreted by geldings fed endophyte-infected seed containing known concentrations of these alkaloids, and the effects of exposure time on clinical expression of toxicosis. METHODS Mature geldings (n=10) received diets containing either endophyte-free (E-) or endophyte-infected (E+) tall fescue seed during three experimenta...

ergovaline, the main ergopeptine alkaloid produced in tall fescue ( fescue arundinacea schreb.) infected with endophyte ( neotyphodium coenophialum morgan- jones & gams), is known to cause tall fescue toxicosis. this study was conducted to examine the presence of fungal endophytes in five populations of tall fescue collected from various regions of iran. the existence of neotyphodium mycelia in...

The 1st outbreak of fescue toxicosis in South Africa was recently confirmed in a Brahman herd at Perdekop, near Standerton, in Mpumalanga province, South Africa. Within 3 weeks of being placed on a fescue pasture in mid-winter, 50 of 385 cattle developed lameness and/or necrosis of the tail. The farmer had established Festuca elatior L. (tall fescue, Iewag variety) on c. 140 ha for winter grazi...