Four accurate, sensitive, and reproducible stability-indicating methods for the determination of erdosteine in the presence of its acid degradation products are presented. The first method involves processing the spectra by using a first-derivative method at 229 nm in a concentration range of 10-70 microg/mL. The mean percentage recovery was 100.43 +/- 0.977. The second method is based on ratio...

BACKGROUND/AIM To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). MATERIALS AND METHODS Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-...

BACKGROUND Carbon dioxide (CO2) pneumoperitoneum facilitates the visualization of abdominal organs during laparoscopic surgery. However, the associated increase in intra-abdominal pressure causes oxidative stress, which contributes to tissue injury. OBJECTIVE We investigated the ability of the antioxidant and anti-inflammatory drug Erdosteine to prevent CO2 pneumoperitoneum-induced oxidative ...

A simple, precise, accurate and sensitive Reverse phase high performance liquid chromatographic (RPHPLC) method for simultaneous estimation of Cefixime trihydrate and Erdosteine in combined capsule dosage form have been developed and validated. Drugs were resolved on a HiQ Sil C8 column (25cm X 4.6mm, 5μm), utilizing mobile phase of TetraButyl Ammonium Hydroxide (0.1 N aqueous) pH adjusted to 6...

Drugs and exogenous toxins, including aminoglyco-sides, amphotericin B, cisplatin, and radiocontrast media , may cause acute kidney injury (1). The manifestations which indicate that damage is occurring are a sudden increase in kidney injury biomarkers (NGAL [neutrophil gelatinase-associated lipocalin], KIM-1 [kidney injury molecule-1], etc.) and kidney failure (creatinine, cystatin C). This im...

THE EFFECT OF MAINTENANCE TREATMENT WITH ERDOSTEINE ON EXACERBATION AND HEALTH STATUS IN PATIENTS COPD: A POST-HOC ANALYSIS RESTORE DATASET Peter M.A. Calverley, Alberto Papi, Clive Page, Paola Rogliani, Roberto W. Dal Negro, Mario Cazzola, Arrigo F. Cicero, Jadwiga A. Wedzicha Aim: To explore the effect of erdosteine on COPD exacerbations, health-related quality life (HRQoL), and subjectively ...

objective(s): to evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (ir) injury. materials and methods: eighteen female wistar albino rats were used in control, ir, and ir+edosteine (ir-e) groups, (n=6 in each). the ir-e group received the erdosteine for seven da...

Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven da...