ERB family receptors (EGFR, ERB-B2, ERB-B3, and ERB-B4) regulate epithelial cell function in many tissue types. In the human airway epithelium, changes in ERB receptor expression are associated with epithelial repair defects. However, the specific role(s) played by ERB receptors in repair have not been determined. We aimed to determine whether ERB receptors regulate proliferation of the tracheo...

Graphical Abstract Highlights d Prostate tumorigenesis caused by PTEN deletion involves loss of estrogen receptor b d ERb transcription is repressed by BMI-1, which is induced by PTEN deletion d ERb repression is needed for tumorigenesis because it enables HIF/VEGF signaling d HIF/VEGF signaling sustains BMI-1 expression, resulting in a positive feedback loop A causal role for ERb in prostate c...

The physiological and behavioral circadian rhythms of most creatures are controlled by a harmony of functional relationships between clock genes. In mammals, several core clock genes show rhythmic profiles of their mRNA and protein expression. Among them, Rev-erb α functions as a transcriptional repressor, affecting expression patterns of other clock genes. For the continuous and robust oscilla...

BACKGROUND Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor (EGFR) family, can contribute to the development of diabetic peripheral neuropathy (DPN). In peripheral nerves, Erb B receptors are activated by various members of ...

The characterization of estrogen receptor beta (ERb) brought new insight into the mechanisms underlying estrogen signaling. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and the mitogenic effects of estrogen in these tissues (such as breast, endometrium and ovary) are well documented both in vitro and in vivo. There is also an emergi...

PURPOSE To determine whether COX-2 expression is associated with clinicopathological parameters, including c-erb-B2 overexpression and angiogenesis, and the disease-free survival of patients with operable breast cancer. MATERIALS AND METHODS Paraffin-embedded tissue samples were selected from 205 patients surgically resected for breast cancer, between 1991 and 1997, and followed-up for at lea...

Acquired resistance to selective estrogen receptor (ER)modulators (SERM) and downregulators (SERD) is a significant clinical problem in the treatment of estrogen (E2) receptor-positive (ERþ) breast cancers. There are two ER subtypes, ERa and ERb, which promote and inhibit breast cancer cell proliferation, respectively. Although ERþ breast cancers typically express a high ratio of ERa to ERb, th...

The process of cell division, growth, differentiation and death is a highly regulated process. Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) a member of Receptor Tyrosine Kinase (RTK) family are best known. These comprises of four receptors Erb B1/HER 1, Erb B2 / HER 2, Erb B3/ HER 3, and Erb B4 / HER 4. Of these H...

This is a report from the project Services In Innovation, Innovation In Services – Services in European Innovation Systems (SI4S). This project has been funded by the European Commission, through the Targeted Socio-Economic Research Programme (TSER), within Area I: Evaluation of science and technology policy options in Europe under contract no. ERB-SOE1-CT-96-1015. Contributions of the TSER pro...