Aromatase inhibition is an effective treatment strategy for breast cancer. Currently, several in silico methods have been developed for the prediction of aromatase inhibitors (AIs) using artificial neural network (ANN) or support vector machine (SVM). In spite of this, there are ample opportunities for further improvements by developing a simple and interpretable quantitative structure-activity...

In this paper, we consider the adaptive Eulerian–Lagrangian method (ELM) for linear convection-diffusion problems. Unlike the classical a posteriori error estimations, we estimate the temporal error along the characteristics and derive a new a posteriori error bound for ELM semi-discretization. With the help of this proposed error bound, we are able to show the optimal convergence rate of ELM f...

This paper presents an analysis of the recently proposed sparse Extreme Learning Machine (S-ELM) classifier and describes an optimization scheme that can be used to calculate the network output weights. This optimization scheme exploits intrinsic graph structures in order to describe geometric data relationships in the so-called ELM space. Kernel formulations of the approach operating in ELM sp...

Predicting reservoir water levels helps manage droughts and floods. level is complex because it depends on factors such as climate parameters human intervention. Therefore, predicting needs robust models. Our study introduces a new model for levels. An extreme learning machine, the multi-kernel least square support vector machine (MKLSSVM), developed to predict of in Malaysia. The also novel op...

In a moment when the study of outlier robustness within Extreme Learning Machine is still in its infancy, we propose a method that combines maximization of the hidden layer’s information transmission, through Batch Intrinsic Plasticity (BIP), with robust estimation of the output weights. This method named R-ELM/BIP generates a reliable solution in the presence of corrupted data with a good gene...

introduction: manipulation of protein stability is important for understanding the principles that govern protein thermostability, both in basic research and industrial applications. various data mining techniques exist for prediction of thermostable proteins. furthermore, ann methods have attracted significant attention for prediction of thermostability, because they constitute an appropriate ...