Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity against staphylococci, enterococci, pneumococci, and streptococci which was considerably better than that of trimethoprim (TMP). EPM was also active against TMP-resistant strains, although the MICs were still relatively high. Its combination with dapsone (DDS) was syne...

Understanding how hepatic precursor cells can generate differentiated bile ducts is crucial for studies on epithelial morphogenesis and for development of cell therapies for hepatobiliary diseases. Epimorphin (EPM) is a key morphogen for duct morphogenesis in various epithelial organs. The role of EPM in bile duct formation (DF) from hepatic precursor cells, however, is not known. To address th...

A major public health challenge is to communicate effectively with vulnerable populations about preparing for disasters and other health emergencies. People who are Deaf or Hard of Hearing (Deaf/HH) and older adults are particularly vulnerable during health emergencies and require communications that are accessible and understandable. Although health literacy studies indicate that the readabili...

1 Pós-graduando do Departamento de Otorrinolaringologia da EPM-UNIFESP. 2 Pós-graduando do Departamento de Otorrinolaringologia da EPM-UNIFESP. 3 Pós-graduando do Departamento de Otorrinolaringologia da EPM-UNIFESP. 4 Docente do departamento de Otorrinolaringologia da EPM-UNIFESP. 5 Docente do departamento de Otorrinolaringologia da EPM-UNIFESP. Escola Paulista de Medicina-UNIFESP. Endereço par...

OBJECTIVES To assess tolerance of esophageal pressure monitoring (EPM) among 5- to 13-year-old children during research polysomnography at study entry and again 1 year later. DESIGN Prospective, observational study. SETTING University-based sleep laboratory. PARTICIPANTS Children scheduled for adenotonsillectomy or hernia repair. INTERVENTIONS None; all operations were performed for cli...

The primary goal of this study was to develop and test a social exchange model of employee reactions to electronic performance monitoring (EPM) to help managers use EPM more effectively. This study proposed that certain EPM practices are related to perceptions of interpersonal and informational justice, which in turn build trust in the manager, along with other important attitudes and outcomes....

1 MD (first-year ENT resident at EPM-UNIFESP). 2 MD (second-year ENT resident at EPM-UNIFESP). 3 MD (PhD and Associate Professor at EPM-UNIFESP). 4 MD (PhD and Associate Professor at EPM-UNIFESP). Escola Paulista de Medicina Universidade Federal de São Paulo (EPM-UNIFESP). Send correspondence to: Renata Caroline Mendonça Ferraz. Rua Machado Bittencourt, 379, ap 81, Vila Clementino. São Paulo SP...

Prior literature documents that the Sharpe ratio (SR) generates biases in performance evaluation if returns distribution deviates from normal because SR is derived under mean-variance model with strict assumption of either quadratic preferences or customarily distributed returns. When return distributions deviate normality, it may lead to unreasonable results. Therefore, this study examines whi...

Equine protozoal myeloencephalitis (EPM) is the most commonly diagnosed infectious neuro-degenerative condition in horses and neuroinflammation is present in all definitively diagnosed cases. Historically EPM is difficult to treat. Polyneuritis equi (cauda equina neuritis) is a rarely recognized noninfectious, chronic relapsing, peripheral neurodegenerative disorder in horses. We propose that p...

This writing aims to find out whether PT EPM has previously implemented tax planning of income owed its company, know the strategy that can be applied EPM, and influence when implementing (tax planning) income. Primary data used in form interviews is get company information not listed documents, then secondary / loss statements annual returns Agency 2019. Data analysis methods use quantitative ...