objective: a recent field of research in epigenetics is dna methylation which involves the cpg island in the genome that subsequently controls transcription and translation of targeted genes. in the hepatitis b virus (hbv) genome, there are three cpg islands which tend to be methylated. the aim of the current study is to determine the methylation pattern of the hbv x gene in chronically infecte...

the epigenetic alterations like histone modifications , dna methylation and others remarkable categories  including nucleosome remodeling and rna mediated targeting have been strongly investigated  recently .in this way , beside the notable importance of dna methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. moreover, the fluctuati...

differentiation of stem cells from a pluripotent to a committed state involves global changes in genome expression patterns, the best known as “epigenetic modifications”. epigenetic mechanisms, including histone modifications, dna methylation and non-coding rna-mediated regulatory events are considered as the essential factors to control the heritable cellular memory of gene expression during d...

Background: At the outset of the somatic cell nuclear transfer (SCNT) process, the chromatin structure of the somatic cell which governs its state of differentiation undergoes dramatic changes, called reprogramming, and is compelled back to the embryonic stage. However, the overall epigenetic makeup of the resultant cloned embryos has been acknowledged far different from the fertilized embryos....

Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...

objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...

asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsible for the development of asthma. increasing rate of asthma incidence during past decades has impl...

sulfur mustard (sm, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes dna alkylation, protein modification and membrane damage. sm can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. epigenetic regulation of gene expression is a growing research topic and is ...

Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. Epigenetic regulation of gene expression is a growing research topic and is ...