BACKGROUND Menstrual blood-derived stem cells (MenSCs) are a novel source of stem cells that can be easily isolated non-invasively from female volunteered donor without ethical consideration. These mesenchymal-like stem cells have high rate of proliferation and possess multi lineage differentiation potency. This study was undertaken to isolate the MenSCs and assess their potential in differenti...

It is known that epidermal cells have experienced assault can induce more effective wound healing responses to any subsequent injuries as in innate immune cells. Herein we show wounds a robust effect on distinct stem than previously thought. Of particular relevance, the first activated cell adaptation program only specific lineage. We discovered population lineage produced memory progenitors re...

Epidermal stem cells control the homeostasis and regeneration of skin hair through their ability to self-renew for extended periods time differentiation into multiple lineages. KROX20, a zinc finger-containing transcription factor, mediates signaling pathways modulate cell activation quiescence in various tissues. In recent study, we identified population epithelial-derived Krox20-expressing up...

PURPOSE To identify the lineage that contributes to the morphogenesis of the meibomian gland. METHODS To examine which cell lineage gives rise to the meibomian gland, the expression of Pax6 as well as that of various cytokeratin markers, including keratin 14 (Krt14), Krt15, Krt4, and Krt10, was examined with immunofluorescent staining of C57BL/6J mouse eyelids from P2 to P11 pups and adult mi...

This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated science. The study of epithelial stem cell biology was aided by the ability to visualize the distribution of stem cells and their progeny through...

We use a new cell marker to study cell lineage of the epidermis, oenocytes and ventral muscles in the Drosophila abdomen. We find that while the epidermal cells and the oenocytes share common precursors until late in development, the muscles derive from a separate lineage. Marked clones in the muscles, but not in the epidermis and oenocytes, can occasionally extend between neighbouring segments...

Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted numb...

Sustained epidermal Wnt/b-catenin signalling expands the stem cell compartment and induces ectopic hair follicles (EFs). This is accompanied by extensive fibroblast proliferation and extracellular matrix (ECM) remodelling in the underlying dermis. Here we show that epidermal Hedgehog (Hh) and Transforming growth factor-beta (TGF-b) signalling mediate the dermal changes. Pharmacological inhibiti...

Sustained epidermal Wnt/β-catenin signalling expands the stem cell compartment and induces ectopic hair follicles (EFs). This is accompanied by extensive fibroblast proliferation and extracellular matrix (ECM) remodelling in the underlying dermis. Here we show that epidermal Hedgehog (Hh) and Transforming growth factor-beta (TGF-β) signalling mediate the dermal changes. Pharmacological inhibiti...