A father and son presented ten years apart with a fourth ventricle ependymoma. The history, imaging and pathology are presented and the aetiology of familial ependymoma discussed.

multiple primary tumors in a single patient are relatively rare when four or more distinct lesions are considered. herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade soft tissue sarcoma. there was no family history and hereditary syndrome. the genetic analysis was completely normal. to best of our knowledge, t...

The long-term clinical outcome of pediatric intracranial epepdymoma is poor with a high rate of recurrence. One of the main reasons for this poor outcome is the tumor's inherent resistance to chemotherapy. Signal transducer and activator of transcription 3 (STAT3) is overactive in many human cancers, and inhibition of STAT3 signaling is an emerging area of interest in oncology. In this study, t...

Ependymomas are rare tumors of the central nervous system (CNS). They are classified based on tumor histology and grade, but the prognostic value of the WHO grading system remains controversial. Treatment is mainly surgical and by radiation. An improved knowledge of ependymoma biology is important to elucidate the pathogenesis, to improve classification schemes, and to identify novel potential ...

Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most common and posing a significant clinical burden. Its mechanism of pathogenesis, reliable prognostic indicators, and effective treatments other than surgical resection have all remained elusive. Until recently, ependymoma research was hindered by the small number of tumors available for study, lo...

BACKGROUND We sought to determine the surgical treatment and functional outcome and identify the predictors of survival in a retrospective cohort of patients with spinal cord ependymoma using data collected from the Korea Spinal Oncology Research Group database. METHODS The data regarding 88 patients who had been surgically treated for histologically confirmed spinal cord intramedullary and e...

Ependymomas are central nervous system neoplasms that account for a third of all posterior fossa tumors in children. The most common location for infratentorial ependymoma is within the fourth ventricle. We present a case report of malignant transformation of an infratentorial grade II ependymoma in a 2-year-old child who presented with vomiting and visual disturbance. An infratentorial brain t...

Trial therapies for rare cancers are usually selected empirically and often fail during clinical testing. The poor efficiency and limited success of this process is hampered by a lack of accurate models with which to perform preclinical studies, and small patient numbers that are likely to include distinct subtypes. These challenges are further compounded by increasing evidence that many cancer...

Introduction Myxopapillary ependymoma is a rare glial tumor with almost exclusive localization in the distal spinal cord (intraspinal variant) or the sacrococcygeal subcutaneous tissue (extraspinal variant). The average age at manifestation has been reported to be approximately 36 years. The overall incidence is approximately 0.08 per 100,000 persons per year for males and 0.05 per 100,000 pers...

Ependymoma can spread via cerebrospinal fluid, but late spinal recurrences of intracranial tumor are very rare. We describe a case of a 33-year-old male who presented with multiple, delayed, recurrent lesions in the spinal cord from an intracranial ependymoma. The patient underwent gross total resection and postoperative radiation therapy 14 years prior to visit for a low grade ependymoma in th...