MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels. Herein, we show that miR-21 is up-regulated during IL-5-driven eosinophil differentiation from progenitor cells in vitro. Targeted ablation of miR-21 leads to reduced eosinophil progenitor cell growth. Furthermore, miR-21(-/-...

A 60-year-old asymptomatic man attended following positive faecal occult blood testing in the UK bowel cancer screening programme. He was a regular carer for young grandchildren. Recent tests showed an elevated eosinophil count (0·82 × 109 cells per L [range 0·04–0·4]). Colonoscopy patchy erythema and erosions with multiple Enterobius vermicularis (threadworm or pinworm) caecum (figure, A). His...

objective(s) considering fair response to inhaled corticosteroids and reports of severe air way hyper responsiveness in chemical warfare victims (cwv), a role for eosinophilic inflammation (i.e. asthma) was postulated. the objective of this study was to determine the presence of eosinophilic inflammation in cwv by evaluation of sputum cellularity and eosinophil cationic protein (ecp). materials...

eosinophils when compared with medium alone. Interestingly, blocking the activity of cysteinyl Leukotries using antagonists inhibited eosinophil-derived ASM proliferation. Conclusions: Eosinophils enhances the proliferation of ASM cells. This role of eosinophil does not seem to depend on ASM derived ECM proteins nor on Eosinophil derived TGF-b or TNF-a. Eosinophil seems to induce ASM proliferat...

A method for in situ staining and scoring of eosinophil colonies and clusters in the whole culture dish has been developed for agar cultures of human marrow cells. Cultures stimulated by human placental conditioned medium were found to develop the same proportion of eosinophil, neutrophil, and monocyte colonies as cultures stimulated by conventional peripheral white cell underlayers. Eosinophil...

eosinophils when compared with medium alone. Interestingly, blocking the activity of cysteinyl Leukotries using antagonists inhibited eosinophil-derived ASM proliferation. Conclusions: Eosinophils enhances the proliferation of ASM cells. This role of eosinophil does not seem to depend on ASM derived ECM proteins nor on Eosinophil derived TGF-b or TNF-a. Eosinophil seems to induce ASM proliferat...

The results of our comparative analysis parameters the leukocyte blood system underyearlings and mature specimens common viper Vipera berus are presented. material was 36 females 26 males caught in Middle Volga basin, 13 born captivity from 4 this sample. V. b. differed: by a lower content heterophils azurophils, an increased eosinophils basophils, increase shift index, decrease lymphocytic–gra...

Eosinophil localization to cholinergic nerves occurs in a variety of inflammatory conditions, including asthma. This localization is mediated by interactions between eosinophil integrins and neuronal vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Eosinophil-nerve cell interactions lead to generation of neuronal reactive oxygen species and release of e...

Eosinophils adhere to airway cholinergic nerves and influence nerve cell function by releasing granule proteins onto inhibitory neuronal M(2) muscarinic receptors. This study investigated the mechanism of eosinophil degranulation by cholinergic nerves. Eosinophils were cocultured with IMR32 cholinergic nerve cells, and eosinophil peroxidase (EPO) or leukotriene C(4) (LTC(4)) release was measure...

Quantitative determinations were made of the capacity of isogenic bone marrow, spleen, and thymic cells from primed and/or nonprimed mice to repopulate the hemopoietic tissues and to mount an inflammatory and antibody response to specific antigen (tetanus toxoid) in heavily irradiated and reconstituted recipients. Spleen cells from primed mice but not from normal mice had the capacity to adopti...