background: we aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (agnp, 5-10 nm) in human hepatoblastoma (hepg2) cell line after and during a period of about one month. methods: xtt and mtt assays were used to draw a dose-response curve ic50 (half maximal inhibitory concentration) value of the agnp on hepg2 cells was calculated to be 2.75-3.0 mg/l...

background and aims: cytomegalovirus (cmv) is a member of herpesviruses. it is one of the most common cause of congenital and prenatal infections. cmv infection of pregnant women, especially in the first trimester may lead to congenital abnormalities in the newborns. the prevalence of cmv infection in developed countries is about 40% and in developing countries may be 100%. because there is no ...

background: blindness due to cataract is a major and important problem in pakistan. the problem is expected to increase in future due to increase in tobacco smoking. the aim of study was to look for the mechanism associated with metal deposition and its effect on antioxidant enzymes in lens of smokers in karachi, pakistan. methods: 20 cataract patients were randomly selected from out patient de...

background: besides acute lethal cyanide poisoning, its chronic intoxication may also produce some pathologic effects on different tissues that precedes alterations in biochemical parameters. the present study was aimed to evaluate the effects of sublethal cyanide exposure on some tissue enzyme activities in liver and kidney of rats. methods: twelve male rats were divided into two groups as fol...

objective: the entry of toxoplasma gondii into the bloodstream and other tissues (such as liver, muscle, cardiac muscle, …) of intermediate hosts and its multiplication in nucleated cells may cause changes in plasma levels of various enzymes due to tissue damage. in present study the serum levels of ast, alt, alk/p, cpk, ldh, and acp in rats infected experimentally with toxoplasma gondii have b...

background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

in this study, the effects of dietary egg lecithin on digestive enzymes and body biochemical composition of juveniles mesopotamichthys sharpeyi was evaluated. four experimental diets including control diet (with 0% egg lecithin) and three diets containing 2%, 4% and 6% egg lecithin were used. at the end of the experiment, digestive enzymes activity (lipase, amylase and alkaline phosphatase) and...