BACKGROUND AND THE PURPOSE OF THE STUDY Amphotericin B (AmB) which is an appropriate antibiotic for the treatment of mycosis has many toxic effects including nephrotoxicity. Recently preparation of a new drug loaded nanoparticles for the reduction of toxicity and increase in the effectiveness of AmB has been reported. The objective of this study was to prepare and evaluate in vitro and in vivo ...

The aim of this investigation was to prepare, characterize and optimize the vinblastine sulphate loaded proniosomes for overall improvement in the physical stability and to prolong the release time in a controlled manner there by increasing its efficacy and to reduce its toxicity and to study the suitability of proniosomes as the carrier of drug. Proniosomes of vinblastine sulphate were prepare...

Entrapment in flowable agricultural material continues to be a relevant problem facing both farmers and employees of commercial grain storage and handling operations. While considerable work has been done previously on the causes of entrapment in grain and possible preventative measures, there is little research on the efficacy of current first response or extrication techniques. With the recen...

because of poor survival of probiotic bacteria, microencapsulation evolved from the immobilized cell culture technology used in the biotechnological industry. two probiotic strains, bifidobacterium (bb-12) and lactobacillus acidophilus (la-5) were immobilized in calcium alginate by extrusion method. encapsulation parameters and efficacy of this method were evaluated. growth factors of these two...

Minoxidil and Rosemary essential oil have been used for several years to stimulate hair growth. Therefore, coadministration of both Minoxidil and Rosemary essential oil could enhance hair growth. The chemical/biological characteristics of liposomes, which encapsulate both hydrophobic and hydrophilic drugs, can be utilized to encapsulate the herbal and chemical drug concoction concomitantly. A t...

CONTEXT Polymeric carrier systems of paclitaxel (PCT) offer advantages over only available formulation Taxol® in terms of enhancing therapeutic efficacy and eliminating adverse effects. OBJECTIVE The objective of the present study was to prepare poly (lactic-co-glycolic acid) nanoparticles containing PCT using emulsion solvent evaporation technique. METHODS Critical factors involved in the ...

Specific delivery of therapeutic agents to solid tumors and their bioavailability at the target site are the most clinically important and challenging goals in cancer therapy. Liposomes are promising nanocarriers and have been well investigated for cancer therapy. In spite of preferred accumulation in tumors via the enhanced permeability and retention (EPR) effect, inefficient drug release at t...

UNLABELLED Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and a frequent cause of sick leave because of work-related hand overload. The main treatment is operation. AIM The aim of the study is to assess the usefulness of high frequency ultrasound in the postoperative evaluation of CTS treatment efficacy. MATERIAL AND METHODS Sixty-two patients (50 women and 12 men age...