antineutrophil cytoplasmic autoantibodies were detected in patients with some autoimmune and vascular disease such as wegner’s granulomatosis polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique was employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic autoantibodies were seen: a cytoplasmic (c-anca) a...

This study aimed to assess the morphometry of enterocytes as well goblet cell-to-enterocyte ratio in different intestinal segments dogs with chronic enteropathies (CE). Histopathological samples from 97 were included (19 healthy juveniles, 21 adults, 24 protein-losing enteropathy (PLE), and 33 CE without PLE). Healthy adult small showed progressively reduced epithelial cell height aboral direct...

Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-co...

Necrotizing enterocolitis (NEC) is associated with the release of interferon-gamma (IFN) by enterocytes and delayed intestinal restitution. Our laboratory has recently demonstrated that IFN inhibits enterocyte migration by impairing enterocyte gap junctions, intercellular channels that are composed of connexin43 (Cx43) monomers and that are required for enterocyte migration to occur. The mechan...

background chronic hepatitis c virus (hcv) is associated with extra hepatic autoimmune disorders, while peg-ifna-2a/rbv combination therapy may exacerbate these conditions. autoantibodies to cytoplasmic structures, called rod and ring particles (rr), have strong associations with these patients and are identified by hep-2 cells. objectives our purpose was to study the correlation of autoantibod...

The current study has examined whether drugs that are transported to the systemic circulation via intestinal lymph (and therefore associate with lipoproteins within enterocyte) accessible enterocyte-based metabolic processes. impact of changes mass lipid present precursor pool (LLPP) on extent drug metabolism also been addressed. Low (5 mg oleic acid/h) or high [20 acid/5.2 lyso-phosphatidylcho...

The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body. Until recently, the molecular mechanisms underlying iron absorption and iron homeostasis have remained a mystery. This review focuses on the proteins and regulatory mechanisms known to be present in the enterocyte precursor cell and in the mature enterocyte. The recen...