MOTIVATION RIP-chip is a high-throughput method to identify mRNAs that are targeted by RNA-binding proteins. The protein of interest is immunoprecipitated, and the identity and relative amount of mRNA associated with it is measured on microarrays. Even if a variety of methods is available to analyse microarray data, e.g. to detect differentially regulated genes, the additional experimental step...

Motivation Deciphering relevant biological insights from epigenomic data can be a challenging task. One commonly used approach is to perform enrichment analysis. However, finding, downloading and using the publicly available functional annotations requires time, programming skills and IT infrastructure. Here we describe the online tool EpiAnnotator for performing enrichment analyses on epigenom...

measurements of pb, cu, zn, as, ni, hg, and fe heavy metals and major elements and components such as ca, hco3, so4, na, k, mg and cl in soluble rain fractions were performed on rainwater collected at arak plain during the rainy seasons of 2012. concentrations of the heavy metals in the soluble fractions decreased for fe, pb, zn, ni, cu, as and hg, respectively and the major elements and compon...

Introduction: Work-family conflict is a common problem among pre-hospital emergency technicians. The present study investigates the effects of applying time management skills on family-work conflict and work-family enrichment in pre-hospital emergency technicians. Methods: In this quasi-experimental study, eight emergency bases located in Birjand, Iran, were divided into two blocks: block A a...

MOTIVATION Multivariate experiments applied to mammalian cells often produce lists of proteins/genes altered under treatment versus control conditions. Such lists can be projected onto prior knowledge of kinase-substrate interactions to infer the list of kinases associated with a specific protein list. By computing how the proportion of kinases, associated with a specific list of proteins/genes...

background: platelet preparations have been used for a wide variety of clinical applications such as hemorrhage, tissue engineering and cellular therapy. platelet concentrates can be prepared by the apheresis method or from the whole blood using the buffy-coat or platelet-rich plasma methods. the purpose of this study was to compare four variations of platelet-rich plasma method based on double...

supplier selection is a multi-criteria problem. this study proposes a hybrid model for supporting the suppliers’ selection and ranking. this research is a two-stage model designed to fully rank the suppliers where each supplier has multiple inputs and outputs. first, the supplier evaluation problem is formulated by data envelopment analysis (dea), since the regarded decision deals with uncertai...

eight selected heavy metals (cu, zn, pb, cd, cr, mn, fe and al) in surface and sub-surfacesediments in the northern coast of sfax (tunisia) were studied in order to assess the sediment quality and tohighlight the anthropogenic contributions to heavy metal distributions in the two study sediment levels.multiple chemometric approaches based on geographic information system (gis), enrichment facto...