s language Mac/ Eng Mac/ Eng Mac/ Eng Mac/ Eng Mac/ Eng Mac/ Eng Mac/ Eng Eng Frequency Semiannual Annual Semiannual Semiannual Semiannual Semiannual Semiannual Quarterly Table 1: Characteristics of the selected Macedonian medical journals.

Oxidative stress causes endothelial dysfunction and is implicated in the pathogenesis of cardiovascular diseases. Our studies suggested that reactive oxygen species (ROS) play a crucial role in hereditary hemorrhagic telangiectasia (HHT) disease, a vascular dysplasia affecting 1 in 5,000-8,000 people. Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1) genes are responsible ...

Pre-eclampsia is a devastating disease of late (after week 20) pregnancy. The condition features hypertension, proteinuria, premature labor, haemolysis, liver abnormalities, thrombocytopenia (HELLP syndrome), seizures (eclampsia) and death [1]. Both mothers and children, if they survive delivery, can expect subsequent increased cardiovascular risk in the future. Preeclampsia affects about 5% of...

Endoglin is a TGF-beta superfamily receptor critical for endothelial cell function. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia type I (HHT1), and clinical signs of disease are generally more evident later in life. We previously showed that systemic vessels of adult Eng heterozygous (Eng(+/-)) mice exhibit increased vasorelaxation due to uncoupling of endoth...

The Wnt (wingless) family of secreted glycoproteins initiates a signalling pathway implicated in the regulation of both normal mouse mammary gland development and tumorigenesis. Multiple Wnt signals ultimately converge on the multifunctional protein beta-catenin to activate the transcription of target genes. Although beta-catenin plays a crucial role in canonical Wnt signalling, it also functio...

Increased levels of a soluble form of endoglin (sEng) circulating in plasma have been detected in various pathological conditions related to cardiovascular system. High concentration of sEng was also proposed to contribute to the development of endothelial dysfunction, but there is no direct evidence to support this hypothesis. Therefore, in the present work we analyzed whether high sEng levels...

Two beta-1,4-endoglucanase (EGase) cDNAs were isolated from Globodera tabacum, the tobacco cyst nematode, and have been designated as GT-eng-1 and GT-eng-2. GT-eng-1 and GT-eng-2 encode precursor proteins with a predicted secretion signal sequence, cellulolytic catalytic domain, and a linker domain. The protein product GT-ENG-1 contains an additional 95 amino acid carboxy terminal sequence with...

Participants: N. Vijaykrishnan, Prof. of Computer Science and Eng. Dept. K. Ünlü, Prof. of Mechanical and Nuclear Eng. Dept. Y. Xie, Prof. of Computer Science and Eng. Dept. M. J. Irwin, Prof. of Computer Science and Eng. Dept. Ramakrishnan Krishnan, Ph.D. student at Electrical Eng. Dept. Rajaraman Ramanarayanan, Ph.D. student at Electrical Eng. Dept. S. M. Çetiner, Ph.D. student at Mechanical ...

The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of intricate changes in vasomotor function in the Eng(+/-) mice and the potential interactions between the NO- and prostaglandin-producing pathways, we assessed the expression and...

1Member of JSCE, Ph.D., Researcher, Dept. of Civil Eng., Univ. of Tokyo (Bunkyo-ku, Tokyo 113-8656, Japan) 2Member of JSCE, Dr. Eng., Professor, Dept. of Civil Eng., Univ. of Tokyo (Bunkyo-ku, Tokyo 113-8656, Japan) 3Member of JSCE, Ph.D., Professor, Inst. of Tibetan Plateau Research, CAS (Beijing 100085, China) 4Ph.D., Professor, Cold and Arid Regions Envi. and Eng. Research Inst., CAS (Lanzho...