Abstract Funding Acknowledgements Type of funding sources: None. Aim To investigate the role markers vascular inflammation, vitamin D, parathyroid hormone as predictors increased pulse-wave velocity (PWV) and degenerative bone changes in postmenopausal women with arterial hypertension (AH). Methods 164 females were examined. Gr.1 included 42 healthy individuals, Gr.2 - 58 patients AH Gr.3 64 os...

aim : this study evaluated the association between serum endothelin- 1 level and symptoms, clinical examination, laboratory and cardio-respiratory parameters, in patients with cirrhosis compared to controls. background : cirrhosis is associated with significant portal, pulmonary and systemic vascular abnormities. recent studies have suggested that endothelin -1 may have a significant role in th...

Chronic heart failure is one of the leading causes death globally, affecting 1.5 to 2% total world population and 2.9 3.9% Western European population. often progresses rapidly in coexistence with endocrine pathology, namely hypothyroidism, that results a more rapid development further progression endothelial dysfunction systemic inflammatory response. The aim our research was study levels endo...

Background. Atopic dermatitis is a chronic multifactorial dermatosis with complex pathophysiological basis. One of the poorly studied links in pathogenesis disease endothelin-1. Its main biological effects include pronounced vasoconstriction blood vessels.
 Aim. To study role endothelin-1 and its autoantibodies atopic dermatitis.
 Materials methods. The included 40 patients common lim...

The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the rabbit in vivo. Endothelin-1 (1-31) (1 nmol/kg, injected into the left cardiac ventricle) induced a monophasic increase of me...

Tspan8 is a member of the tetraspanins family cell surface molecules. The ability to organize membrane microdomains with other molecules and interfere their function suggests that they could act as integrators external or internal signals. Among first identified tetraspanins, promotes tumor progression metastasis, presumably by stimulating angiogenesis motility. In patients, its expression on d...

The present study was designed to determine whether endothelin and "big endothelin" are released from aortic strips with endothelium and to examine the effect of thrombin by using a specific radioimmunoassay. Porcine aortic strips with endothelium released immunoreactive endothelin (ir-endothelin) and immunoreactive big endothelin (ir-big endothelin) into the medium in a time-dependent manner. ...

BACKGROUND Inhaled nitric oxide (iNO) is an established therapy in the treatment of pulmonary hypertension and right ventricular dysfunction following left ventricular assist device implantation. Since it is known that endothelin-1 contributes to pulmonary hypertension, and nitric oxide modulates endothelin-1 synthesis in vitro, we investigated the effects of iNO on circulating endothelin-1 and...