We report the case of a 73-year-old female with myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Grossly, the tumor sized 130 x 130 x 100 mm involved the uterine corpus almost in its entirety. Histologically, the tumor consisted of two cell types. In some areas, the tumor cells showed typical features of endometrial stromal tumors and resembled stromal c...

p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immuno...

Uterine sarcomas are very unique tumors with mesodermial origin and accounting for 2-6% of uterine cancers. In general, uterine sarcomas are the most malignant tumors of the uterus. Their usual histologic types are endometrial estromal sarcoma, lieomyosarcoma and malignant mixed mullerian tumor or carcinosarcoma In this case report, a 19 year old woman with chief complaint of abnormal ute...

Introduction: Endometrial stromal sarcomas usually arise in the uterine corpus while it is rare in extra-uterine sites. The most common extra-uterine site is the ovary. However, primary endometrial stromal sarcoma of the ovary rarely arises in a serous tumor. We report a case of primary ovarian ESS presenting in the wall of a serous cyst along with a synchronous endometrial stromal nodule (ESN)...

Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. The clinical use of progesterone is limited because of the lack of biomarkers that predict hormone sensitivity. Despite its efficacy in cancer therapy, mechanisms and site of action for progesterone remain unknown. Using an in vivo endometrial cancer mouse model...

Reprint requests to: Dr. Wen-Ko Su Department of Radiology, Hsinchu Mackay Memorial Hospital. No. 690, Sec. 2, Guang Fu Road, Hsinchu 30071, Taiwan, R.O.C. Endometrial stromal sarcoma (ESS) is a rare mesenchymal neoplasm that usuallyoccurs as a primary tumor of the uterus. Endometrial stromal sarcomas may occasionally arise in other sites, such as the ovary, mesentery, and vagina. We report an ...

Most of malignant tumors arising in ovarian and extraovarian endometriosis are carcinomas. Mixed mullerian tumor and endometrial stromal sarcoma arising in intestinal endometriosis are rarely described, but its clinicopathologic features have not been well characterized. Here we report a case of endometrial stromal sarcoma of the sigmoid colon arising in endometriosis with a review of six addit...

Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious andwell-tolerated treatment in endometrial cancer. The clinical use of progesterone is limited because of the lack of biomarkers that predict hormone sensitivity. Despite its efficacy in cancer therapy,mechanisms and site of action for progesterone remain unknown. Using an in vivo endometrial cancer mouse model d...

Endometrial stromal nodule (ESN) is the least common of the endometrial stromal tumors. They are rare neoplasms which are diagnosed in most instances by light microscopy. Although such nodules are benign, hysterectomy has been considered the treatment of choice to determine the margins of the tumor required for diagnosis and to differentiate it from invasive stromal sarcoma Whose prognosis is t...

Endometrial stromal tumors are extremely rare uterine malignancy, mainly among young females. Herein, we report a case of low-grade endometrial tumor in 19-year-old women who presented with the non-specific symptoms lower abdominal pain, swelling and vaginal bleeding similar to leiomyoma. Ultrasound finding showed bulky uterus multiple fibroid degenerative changes. Contrast enhanced computed to...