Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawle...

Introduction . Articular cartilage has a limited intrinsic capacity for repair, therefore, methods to repair or reconstruct osteochondral defects have been sought by many labs (). The search for the ideal cellular matrix has resulted in the development and testing of both artificial and natural scaffold materials(). Current cellular scaffolds, however, are limited by the presence of inflammator...

Demineralized bone matrix gelatin (BMG) was implanted into the skeletal muscle of Sprague-Dawley rats, and the resulting ultrastructural changes of the BMG were examined 3, 5, 7, 10, 15 and 20 days later. Most of the implanted BMG became calcified 7-20 days after implantation. Calcification ('acellular mineral deposition') was first observed as needle-shaped crystalline deposits in the BMG matr...

Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawle...

BACKGROUND Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes. OBJECTIVE To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects. METHODS 20 alveolar sockets from 10 healthy adults wer...

Histological changes in cultured neonatal skeletal muscle tissue at the early stage of cartilage induction by syngeneic insoluble bone matrix gelatin (BMG) containing bone morphogenetic protein were examined by light and electron microscopy. Minced skeletal muscle was cultured on hemicylindrical pieces of BMG for 14 days. Chondroblasts first appeared in the crevices of the BMG on Day 7 of the c...

Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaffold to structurally and elastically simulate the annulus fibrosus (AF) tissue ...

different ossificant materials have been used for induction of bone repair in many studies, and bone matrix gelatin which contains bone morphogenic proteins is one of the best ones. in present study we evaluated the role of this material in acceleration of bone repair in rabbit tibia. a hole of 3.5 mm diameter was made on right tibia of 10 and 12 rabbits as study and control group respectively....