the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined...

BACKGROUND Recent publications have questioned the validity of the "lipid sink" theory of lipid resuscitation while others have identified sink-independent effects and posed alternative mechanisms such as hemodilution. To address these issues, the authors tested the dose-dependent response to intravenous lipid emulsion during reversal of bupivacaine-induced cardiovascular toxicity in vivo. Subs...

in this study the effect of basil seed gum (bsg) concentration (0%, 0.005%, 0.02%, 0.08%, 0.15% and 0.3% w/w) on the stability, particle size distribution and rheological properties of o/w emulsion stabilized by whey protein isolate (0.5% w/w) was investigated at neutral ph. the emulsion prepared by using a sonicator with a nominal power output of 150 w and an operating frequency of 20 khz. son...

In situ combustion of a water-in-oil emulsion layer supported on water is a complex process. In this paper, the combustion process of water-in-oil emulsion layers floating on top of a water body, as in the case of in situ burning of oil spilled at sea that has turned into emulsion, is modeled by using comprehensive mathematical treatment, and the results are compared with data obtained in our l...

the purpose of this study is to produce an oil-in-water nano-emulsion by ultrasonication. casein combined with inulin used as continuous phase, while dispersed phase consisted of fish oil. the size of the nano-emulsion and the ph of nano-emulsion were characterized. ultrasound has been used for preparing emulsion by 24 khz intensity for 120 seconds. prepared nano-emulsion was investigated by pa...

conclusion the minimum concentration of triolein emulsion required to increase vascular permeability adequately with minimal brain edema in a cat model was 0.5%. results the lesion hemispheres showed mild hyperintensity due to edema on t2-weighted images, and contrast enhancement on post-contrast t1-weighted images in cats of group 1-5. cers showed statistically significant differences between ...

The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 % (m/m) EGCG were prepared and subjected to photodegradation studies in order to select excipients that minimize the light i...

BACKGROUND Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity. MATERIAL/METHODS In this single-blinded randomized control stud...