The control of size and size distribution of microspheres is necessary for obtaining repeatable controlled release behavior. The chitosan microspheres were prepared by a membrane emulsification technique in this study. Chitosan was dissolved in 1 wt.% aqueous acetic acid containing 0.9 wt.% sodium chloride, which was used as a water phase. A mixture of liquid paraffin and petroleum ether 7:5 (v...

The purpose of this paper was to evaluate the shelf-life of chitosan and cinnamon oil coated chicken meat nuggets under refrigeration conditions. Three types of coated nuggets were developed viz., Meat coated with Chitosan (1%) and Cinnamon oil (0.05%) (T1), direct addition of Chitosan and Cinnamon oil in emulsion (T2) and nuggets dipped in Chitosan and Cinnamon oil (T3) and were aerobically pa...

the effects of a nano-emulsion chitosan-based coating on enhancing the shelf-life and quality of golab kohanz apples were studied. the nano-emulsion coating containing chitosan with a concentration of 2000 ppm was applied for coating of golab kohanz apples. coated and uncoated apples were packed in normal packaging cardboards and kept at 2 ± 1 °c with a relative humidity within 80-85%. flesh fi...

To evaluate the residence of chitosan-coated emulsion (CE) containing indomethacin in tears, the drug retention of CE in tear fluid was compared with non-coated emulsion (NE) after instillation in rabbit eyes. CE had mean concentrations 3.6-fold and 3.8-fold higher than NE at 0.5 h and 0.75 h after instillation, respectively. Mean residence time and half-life of CE were lengthened to 1.5-fold a...

The aim of this study was to evaluate intraocular biodistribution of a fluorescent polymeric nanosystem composed of chitosan and gelatin after intravitreal administration in rat eyes. The nanoparticles based on chitosan and gelatin were synthesized using a reverse emulsion-double cross-linking technique (ionic and covalent) and their structural characteristics are presented. Two units of 1% sus...

Polyelectrolyte-coated nanoparticles or microparticles interact with bioactive molecules (peptides, proteins or nucleic acids) and have been proposed as delivery systems for these molecules. However, the mechanism of adsorption of polyelectrolyte onto particles remains unsolved. In this study, cationic poly(lactide-co-glycolide) (PLGA) nanoparticles were fabricated by adsorption of various conc...

Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and D-glucosamine) is crucial to whether chitosan is predominantly an ampholyte or predominantly a polyelectrolyte at acidic pH-values. The chemical composition is not only crucial to its sur...

Aim: In the present study, the main objective was to develop a multiparticulate system containing chitosan microspheres for colon-specific drug delivery of capecitabine for the treatment of colorectal cancer. Materials and Methods: This study was based on the microbial degradability of chitosan microspheres. The microspheres were prepared with chitosan by emulsion cross linking method. A factor...

Microencapsulation as one of the most modern methods has considerable effects on probiotic survival. In this study Lactobacillus casei (ATCC 39392) and Bifidobacterium bifidum (ATCC 29521) were encapsulated using calcium alginate-gelatinized starch, chitosan coating and inulin via emulsion technique, and were incubated in simulated gastric juice (along with pepsin, pH=1.5) and simulated intesti...

The effect of type of emulsifier, 2 w/w% whey protein concentrate (WPC) or 2 w/w% WPC and 0.1 w/w% chitosan (CH) on the rheological changes and droplet size distribution during the ex vivo digestion of oil in water emulsions (pH 2) containing 1 w/w% rapeseed oil (RSO) were investigated. The procedure was used to mimic the human gastro duodenal digestion in two steps, gastric phase at pH 2 for 3...