Tetrasubstituted (Z)-alkenes were readily prepared through the Horner-Wadsworth-Emmons reactions of methyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate with aryl alkyl ketones by employing Sn(OSO(2)CF(3))(2) and N-ethylpiperidine.

The observed epimerization at C2 in the Horner-Wadsworth-Emmons (HWE) reaction of chiral 2-substituted-4-oxopiperidines has been investigated and, on the basis of the experimental results, a mechanism for this unexpected process has been proposed.

R Kissling, a pillar of US Center for Disease Control (CDC) infectious diseases programs through an era of great programmatic and institutional growth (1947– 1973), died November 13, 2013 at his home in North Carolina. Through his years at CDC, Bob led investigations of great diversity and impact, always with the same sense of openness, integrity, composure, and respect for everyone involved. T...

Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition.

In an earlier paper in Entropy [1] we hypothesized that the entropy generation rate is the driving force for boundary layer transition from laminar to turbulent flow. Subsequently, with our colleagues we have examined the prediction of entropy generation during such transitions [2,3]. We found that reasonable predictions for engineering purposes could be obtained for flows with negligible strea...

A partial order on a job set is called consistent, if it has a linear extension which is an optimal solution to the total tardiness problem of the job set. The concept of proper augmentations of consistent partial orders is based on Emmons' well-known dominance theorem. In this paper, we address the question whether the proper augmentation of a consistent partial order always results in a parti...

A partial order on a job set is called consistent, if it has a linear extension which is an optimal solution to the total tardiness problem of the job set. The concept of proper augmentations of consistent partial orders is based on Emmons’ well-known dominance theorem. In this paper, we address the question of whether the proper augmentation of a consistent partial order always results in a pa...

Palladium catalyzed cross coupling reactions of a vinyl triflate intermediate and various alkenyl stannanes afforded trisubstituted Z-olefins stereoselectively in high yields. These olefins were then converted to the corresponding 9Z-retinoic acids via Horner-Emmons reaction and subsequent basic hydrolysis in excellent yields.

The first enantioselective synthesis of palinurin has been accomplished starting from commercially available furaldehyde and (R)-methyl-3-hydroxy-2-methylpropionate; the key steps of the synthesis include the use of a chiral pyrrolidine to create the chiral tetronic moiety, and Horner-Wadsworth-Emmons, Wittig and Wittig-Horner reactions to construct the alkene units.