Elastin-like polypeptides (ELPs) undergo a characteristic phase transition in response to ambient temperature. Therefore, it has been be used as thermosensitive vector for the delivery of chemotherapy agents since can target hyperthermic tumors. This novel strategy introduces unprecedented options treating cancer with fewer concerns about side effects. In this study, ELP system was further modi...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short half-life. Thermally responsive elastin-like polypeptides (ELPs) are a promisin...

This article discusses the status of existing English language proficiency (ELP) tests, and compares the content coverage and psychometric characteristics of ELP assessments that existed prior to the implementation of the No Child Left Behind Act (NCLB) with those developed after NCLB Title III guidelines were introduced. The article argues that the newly developed ELP assessments (post-NCLB) e...

Current therapies for the treatment of pancreatic cancer are limited. The limitations of this type of treatment are abundant. The majority of chemotherapeutic agents used in clinics are highly toxic to both tumor cells and normal tissues due to the lack of specificity. Resistance can develop due to overexposure of these agents. To address these issues, these agents must be made more exclusive t...

BACKGROUND Elastin-like polypeptides (ELPs) are useful tools that can be used to non-chromatographically purify proteins. When paired with self-cleaving inteins, they can be used as economical self-cleaving purification tags. However, ELPs and ELP-tagged target proteins have been traditionally expressed using highly enriched media in shake flask cultures, which are generally not amenable to sca...

Elastin-like polypeptides (ELP) aggregate in response to mild hyperthermia, but remain soluble under normal physiologic conditions. ELP macromolecules can accumulate in solid tumors because of the enhanced permeability and retention effect. Tumor retention of ELPs can be further enhanced through hyperthermia-induced aggregation of ELPs by local heating of the tumor. We evaluated the therapeutic...

Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities of the drug conjugates. Herein, we described a unique delivery system compris...

We show that submicron-sized patterns can be imprinted into soft, recombinant-engineered protein hydrogels (here elastin-like proteins, ELP) by transferring wavy patterns from polydimethylsiloxane (PDMS) molds. The high-precision topographical tunability of the relatively stiff PDMS is translated to a bio-responsive, soft material, enabling topographical cell response studies at elastic moduli ...

Abstract Although mineral trioxide aggregates (MTA) have been adopted as an endodontic sealer because of excellent sealing effect and bioactive property modified with improvement its characteristics, the developed MTA sealers not yet satisfied all ideal requirements sealers. The aim this study was to assess characteristics elastin-like polypeptide (ELP)-incorporated for use compare them those c...

We introduce ELP as a decidable fragment of the Semantic Web Rule Language (SWRL) that admits reasoning in polynomial time. ELP is based on the tractable description logic EL, and encompasses an extended notion of the recently proposed DL rules for that logic. Thus ELP extends EL with a number of features introduced by the forthcoming OWL 2, such as disjoint roles, local reflexivity, certain ra...