introduction: this study was designed to investigate the effects of music in wistar rats after sub-chronic treatment of simvastatin. the rats were orally administered with either simvastatin or saline (controls). after 4 weeks of drug treatment, the rats were selected for behavioral studies. the rats were exposed to music 24 hours before behavioral tests (mozart’s piano sonata, kv361, largo). r...

one of the main components of the stress system is hypothalamus- pituitary-adrenal (hpa) axis. acute activation of µ-opioid receptors increases the activity of the hpa axis, leading to release of acth and corticosterone. glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. in this experiment, effect...

introduction: fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. estrogens affect anxiety through neurochemical systems such as gaba-a receptors. in this study the effects of fennel on gaba-a and estrogen receptors in anxiety were investigated. methods: adult female wistar rats weighing (180±20 g) were divided into 8 groups. groups received saline, fennel (200, 500,...

introduction: dracocephalum polychaetum bornum is exclusively found in a limited geographical area in the kerman province it is used by the local people for treatment of abdominal pain, meteorism and musculoskeletal pain. no study has been performed on the effects of d. polychaetum bornum, so the aim of this work was to assess the role of the extract and essential oil of this plant on pain and ...

introduction: in this study, we investigated the role of n-methyl-d-aspartate (nmda) receptors in the ventral hippocampus (vh) and their possible interactions with gabaa system on anxiety-like behaviors. methods: we used an elevated-plus maze test (epm) to assess anxiety-like behaviors and locomotor activity in male wistar rats. results: the results showed that intra-vh infusions of different d...

anxiety symptoms have been reported to be present in many patients with diabetes mellitus. however, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. we assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. our findin...

conclusions acute and chronic administration of ellagic acid had anxiolytic property. also, the most effective dose of ellagic acid was 30 mg/kg. pretreatment with flumazenil reversed the beneficial effect of ellagic acid and diazepam on anxiety. it is likely that the anxiolytic effect of ellagic acid is largely mediated by activation of gabaa receptor. results acute and chronic application of ...

I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus- Maze” by Komaki et al. (2015). In this valuable article, the authors uncovered the effects of AM251 as a CB1 receptor antagonist on anxiety-like behaviors of rats using elevated plus-maze