OF DOCTORAL DISSERTATION HELSINKI UNIVERSITY OF TECHNOLOGY P. O. BOX 1000, FI-02015 TKK http://www.tkk.fi Author Mika Särkelä Name of the dissertation Manuscript submitted Dec. 11, 2007 Manuscript revised Mar. 10, 2008 Date of the defence Apr. 18, 2008 Article dissertation (summary + original articles) Monograph Faculty Department Field of research Opponent(s) Supervisor Instructor Abstract

INTRODUCTION The increased morbidity and mortality and poorer quality of life associated with drug-resistant epilepsy justify admitting patients to epilepsy monitoring units (EMU). These units employ methods that promote the occurrence of seizures, which involves a risk of secondary adverse events. The aim of our study is to characterise and quantify these adverse events in a Spanish EMU. MAT...

Background: The electroencephalogram has been largely supplanted by neuroimaging techniques for the diagnosis and localization of ischemic stroke. However, because of its close correlation with cerebral metabolism and its ability to detect brief transient alterations in cortical function, the electroencephalogram may still be useful for certain diagnostic applications in stroke. Summary of Revi...

BACKGROUND Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described. OBJECTIVE To present the clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis. PATIENTS AND METHODS Twenty-four patients...

The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce distinct brain states that are readily visible in the electroencephalogram. We present a two-part rev...