Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). After initial selectin-mediated tethering and rolling, firm adhesion of lymphocytes requires rapid upregulation of lymphocyte integrin adhesiveness. This step is mediated in part by the HEV-derived chemokine SLC (secondar...

BACKGROUND A dominant T helper type 1 (Th1) immune response is thought to be involved in Crohn's disease (CD). SLC/CCL21 and ELC/CCL19, chemokines that regulate T cell homing and promote recirculating T and dendritic cell (DC) interactions, help control antigen specific T cell responses. AIMS To investigate the Th1 response and SLC and ELC in CD pathogenesis. METHODS Surgically resected int...

BACKGROUND Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis. METHODS AND RESULTS The mean terminal restriction fragment (TRF) was determined by Southern...

The study aimed to compare the application values of endoscopic-laparoscopic cholecystolithotomy (ELC) and laparoscopic cholecystectomy (LC) for patients with cholecystolithiasis. It did a retrospective analysis of 107 patients with cholecystolithiasis who underwent ELC and 144 patients with cholecystolithiasis who underwent LC. There is no significant difference in operating time and expenses ...

EBI1-ligand chemokine (ELC) is a CC chemokine constitutively expressed in various lymphoid tissues and a high-affinity functional ligand for EBI1/CCR7, a seven transmembrane G-protein-coupled receptor originally identified as an Epstein-Barr virus (EBV)-inducible gene. Here we examined chemotactic activity of ELC on peripheral blood leukocytes. ELC attracted both CD4+ and CD8+ T cells, particul...

OBJECTIVES Several studies have found a significant association between the presence of earlobe crease (ELC) and cardiovascular disease (CVD). Brachial-ankle Pulse Wave Velocity (baPWV) is a non-invasive and useful measure of arterial stiffness predicting cardiovascular events and mortality. However, few studies have reported the relationship between ELC and baPWV as a new measure of arterial s...

A Fibonacci string is a length n binary string containing no two consecutive 1s. Fibonacci cubes (FC), Extended Fibonacci cubes (ELC) and Lucas cubes (LC) are subgraphs of hypercube defined in terms of Fibonacci strings. All these cubes were introduced in the last ten years as models for interconnection networks and shown that their network topology posseses many interesting properties that are...

Orbits of graphs under the operation edge local complementation (ELC) are defined. We show that the ELC orbit of a bipartite graph corresponds to the equivalence class of a binary linear code. The information sets and the minimum distance of a code can be derived from the corresponding ELC orbit. By extending earlier results on local complementation (LC) orbits, we classify the ELC orbits of al...

BACKGROUND : A recent systematic review found early laparoscopic cholecystectomy (ELC) to be safe and to shorten total hospital stay compared with delayed laparoscopic cholecystectomy (DLC) for acute cholecystitis. The cost-effectiveness of ELC versus DLC for acute cholecystitis is unknown. METHODS : A decision tree model estimating and comparing costs to the UK National Health Service (NHS) ...