In this paper, the effect of house envelopes including thermal bridges on daily, monthly, and annual consumption air conditioning system a detached an attached house, with façade in east, west, north, or south direction, is investigated; moreover, capacity calculated for houses based maximum hourly peak load during severe weather conditions. The four tested are exterior insulation finish (EIFS)...

In this paper, three-dimensional modeling of the fatigue crack growth profiles was performed in a simple riveted lap joint. Simulation results showed that mode I was dominated on the one side of the plates and the crack straightly grew on this side, while the other side of the plates was in a mixed-mode condition and the crack propagation path was not straight on this side. Afterward, the fract...

Earlier, targeting of DDX3 by few viral proteins has defined its role in mRNA transport and induction of interferon production. This study was conducted to investigate the function of bovine adenovirus (BAdV)-3 pVIII during virus infection. Here, we provided evidence regarding involvement of DDX3 in cap dependent cellular mRNA translation and demonstrated that targeting of DDX3 by adenovirus pr...

With the increasing importance of early internationalizing firms (EIFs), recent literature has shown a rapidly growing research interest in EIF performance. To enhance our understanding of what drives EIF performance, we conduct a systematic analysis of performance antecedents and performance measures in current empirical research. This method allows us to: (i) systematically analyze EIF litera...

Infection of BHK cells by Sindbis virus (SV) gives rise to a profound inhibition of cellular protein synthesis, whereas translation of viral subgenomic mRNA that encodes viral structural proteins, continues for hours. To gain further knowledge on the mechanism by which this subgenomic mRNA is translated, the requirements for some initiation factors (eIFs) and for the presence of the initiator A...

T control of gene expression is generally exerted in the initiation phase of protein synthesis. The reactions of the initiation pathway bring the ribosome to the mRNA and place the initiation codon in the peptidyl (P) site of the ribosome, base-paired with the anticodon of methionyl initiator tRNA (MettRNAi ). The aminoacyl (A) site in the ribosome is left open to accept the elongator tRNA that...

Eukaryotic translation initiation is an intricate process involving at least 11 formally classified eIFs (eukaryotic initiation factors), which, together with the ribosome, comprise one of the largest molecular machines in the cell. Studying such huge macromolecular complexes presents many challenges which cannot readily be overcome by traditional molecular and structural methods. Increasingly,...

Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic initiation factors (eIFs). Extensive evidence shows that the transcriptome and corresponding proteome do not invariably correlate with each other...

Eukaryotic translation initiation factors (eIFs) constitute a new class of therapeutic cancer targets. EIF3b is the major scaffold protein of eIF3 (the largest core of eIFs). We sought to define the role played by and the mechanism of action of eIF3b in patients with clear cell renal cell carcinoma (ccRCC). We found that high-level eIF3b expression in tumors was not only associated with an aggr...