the pathogenesis of equine grass sickness (egs) has not fully understood. a better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. previous studies reported some pathological damage of neuronal cells in egs patients. in this study, primarily cytotoxicity of serum from three clinically egs-diagnosed horses on pc12 tet-off (pto) cells was assessed. subs...

Surveillance Equine grass sickness (EGS, equine dysautonomia) remains a frequently fatal polyneuropathy of equids. The Animal Health Trust (AHT) continues to host a nationwide surveillance scheme (http://www.equinegrasssickness.co.uk/), in which data from 1410 EGS cases, collated for the decade 2000-2009, were published previously [1]. Since 2010 a further 642 EGS cases have been reported to th...

BACKGROUND Equine dysautonomia or equine grass sickness (EGS), as it is more commonly known, is a usually fatal disease of equids of uncertain etiology, although associated with grazing, that affects the autonomic and enteric nervous system. Lowered gastrointestinal motility, leading to paralysis of the gut, is one of the main symptoms of EGS. Previous studies have implicated anaerobic bacteria...

External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA. Using murine cytomegalovirus (MCMV) as a model system, we examined the antiviral effects of an EGS variant, which was engineered using in vitro selection procedures...

REASONS FOR PERFORMING STUDY Equine grass sickness (EGS) remains a frequently fatal disease of equids in Britain. Since previous investigations of signalment- and meteorology-related risk factors for EGS have yielded some conflicting data, further investigation is warranted. OBJECTIVES To identify signalment- and meteorology-related risk factors for EGS in Scotland. STUDY DESIGN Retrospecti...

The widely renowned M.I.T. study “The Future of Geothermal Energy” (2006) determined recoverable EGS resources > 200,000 EJ alone for the USA, corresponding to 2,000 times the annual primary energy demand. To universally and globally utilize these immense resources exciting R&D problems need to be tackled: 1) Development of a technology to produce electricity and/or heat from a basically ubiqui...

External guide sequences (EGSs) are oligonucleotides that consist of a sequence complementary to a target mRNA and recruit intracellular RNase P for specific degradation of the target RNA. In this study, DNA-based EGS molecules were chemically synthesized to target the mRNA coding for the protease of human cytomegalovirus (HCMV). The EGS molecules efficiently directed human RNase P to cleave th...

External guide sequences (EGSs) are RNA molecules that consist of a sequence complementary to a target mRNA and recruit intracellular ribonuclease P (RNase P), a tRNA processing enzyme, for specific degradation of the target mRNA. We have previously used an in vitro selection procedure to generate EGS variants that efficiently induce human RNase P to cleave a target mRNA in vitro. In this study...

OBJECTIVE The objectives of this study were 1) to construct new error grids (EGs) for blood glucose (BG) self-monitoring by using the expertise of a large panel of clinicians and 2) to use the new EGs to evaluate the accuracy of BG measurements made by patients. RESEARCH DESIGN AND METHODS To construct new EGs for type 1 and type 2 diabetic patients, a total of 100 experts of diabetes were as...

Overall participation in the Employment Guarantee Scheme (EGS) in Maharashtra (an Indian state) fell sharply over the period 1980-97. Some of this reduction was due to expansion of irrigation facilities leading to expansion of farm employment. Alongside, expansion of non-farm employment led to a further reduction in the demand for the EGS. Although there was a slight rise in participation in su...