Dysregulated human eccrine sweat glands can negatively impact the quality-of-life of people suffering from disorders like hyperhidrosis. Inability of sweating can even result in serious health effects in humans affected by anhidrosis. The underlying mechanisms must be elucidated and a reliable in vitro test system for drug screening must be developed. Here we describe a novel organotypic three-...

INTRODUCTION Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the int...

Eccrine sweat glands are generally considered to be a possible epidermal stem cell source. Here we compared the multilayered epithelia formed by epidermal keratinocytes and those formed by eccrine sweat gland cells. We demonstrated both in vitro and in vivo the capability of human eccrine sweat gland cells to form a stratified interfollicular epidermis substitute on collagen hydrogels. This is ...

BACKGROUND Several subtypes of sweat gland carcinoma have been found to demonstrate a propensity to metastasize systemically and to regional lymph nodes. The predictive value and benefit of sentinel lymph node (SLN) biopsy have been established in numerous other malignancies, but to the authors' knowledge there is little literature published to date regarding the use of SLN biopsy in patients w...

Eccrine porocarcinoma is a rare malignant adnexal tumor of ductal portion of eccrine sweat gland. It occurs commonly in the lower extremities and rarely in scalp, face, ear, trunk and upper extremities. This survey presents a classic case of eccrine porocarcinoma of scalp in a 58 yr old male patient, presenting as cauliflower like growth over parietal aspect of scalp.  

Apocrine glands are the major type of sweat gland in dogs, and distribution of eccrine sweat glands is limited to footpad (Goldschmidt and Shofer, 1992). Apocrine sweat gland tumors are rather common in dogs and tend to occur on the head, neck and limbs. The Golden Retriever is a breed that shows a predisposition to such tumors (Kalaher et al., 1990). The tumor was greatly resembles its human c...

eccrine porocarcinoma is a rare malignant adnexal tumor of ductal portion of eccrine sweat gland. it occurs commonly in the lower extremities and rarely in scalp, face, ear, trunk and upper extremities. this survey presents a classic case of eccrine porocarcinoma of scalp in a 58 yr old male patient, presenting as cauliflower like growth over parietal aspect of scalp.

A case report is presented of eccrine spiradenoma, a benign sweat gland tumour which, though not uncommon generally, is rare in the eyelid. The possibility of sweat gland tumour should be kept in mind in the diagnosis of eyelid tumours.

Sweat gland carcinomas are rare. Given this, they can pose a diagnostic challenge especially in shave biopsy specimens. We present a case of ductal eccrine carcinoma with extensive squamoid differentiation that was repeatedly misdiagnosed by multiple dermatopathologists as squamous cell carcinoma in the initial few biopsies. As the distinction between these two neoplasms is crucial to patient m...

Since the classical work of Köllike r, (1889), a large number of embryological studies on the skin and the sweat gland of the human embryos have been reported by many investigators, including some Japanese such as Nagai (1936), A k a g i (1939) and Ueda (1939). Histochemical studies on the skin and the sweat gland have been carried out by Tak a g i (1941), I t o (1949, 1951) and M ont a gn a (1...