Influence of previous visual stimulus or saccade on saccadic reaction times in monkey. Saccadic reaction times (SRTs) to suddenly appearing targets are influenced by neural processes that occur before and after target presentation. The majority of previous studies have focused on how posttarget factors, such as target attributes or changes in task complexity, affect SRTs. Studies of pretarget f...

PURPOSE To compare measurements of eccentric fixation using two different targets for fixation, a traditional visuoscope target and the streak target of an ophthalmoscope. PATIENTS AND METHODS Monocular fixation was evaluated using visuoscopy in 47 patients ranging in age from 4 months to 22 years. Visuoscopy measurements were compared using both the traditional visuoscope target and the stre...

In a placebo-controlled, double-blind study, we measured the effects of low dose lorazepam on attentional and motor factors involved in saccadic and smooth pursuit eye movements. We manipulated the temporal interval between the extinction of the central fixation target and the appearance of a second eccentric target (gap/overlap step paradigm). The second target was either stationary (saccade t...

Skeletal muscles of the mdx mouse, a model of Duchenne Muscular Dystrophy, show an excessive reduction in the maximal tetanic force following eccentric contractions. This specific sign of the susceptibility of dystrophin-deficient muscles to mechanical stress can be used as a quantitative test to measure the efficacy of therapeutic interventions. Using inducible transgenesis in mice, we show th...

PURPOSE To evaluate the relationship of the endometrial canal and decidua vera to the interstitial gestational sac and to determine if this relationship can be used to increase the predictive value of ultrasound (US) in the diagnosis of interstitial ectopic pregnancy. MATERIALS AND METHODS The US findings in 12 patients with interstitial ectopic pregnancy were reviewed. Radiologists also revi...

PURPOSE This study examined the ability of 10 young (25.3 +/- 2.8 yr) healthy individuals to control knee-extension force during several discrete concentric and eccentric contractions. METHODS Subjects performed maximal and submaximal tasks on a KIN-COM isokinetic dynamometer. The submaximal tasks were to match a force-time parabola with a time to peak force of 200 ms at five target-forces (5...