Small-conductance (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both KCa2 and KCa3.1 channels with similar potency or, as in the case of CyPPA and NS13001, selectively activate KCa2.2 and KCa2.3 channels. We...

background: the german cockroach, blattella germanica l . , is a serious household and public health pest worldwide. con­trol of this species has been very difficult to achieve. toxicity of cypermethrin ec10%, deltamethrin ec5%, diazi­non ec0.5%, lambda-cyhalothrin ec5% and negon® (permethrin+propoxur oil liquid1%) commercial for­mula­tions were investigated against adult males of german cockro...

T-cadherin (T-cad) promotes survival, proliferation, and migration of endothelial cells and induces angiogenesis. We aimed to identify domains of T-cad functionally relevant to its effects on endothelial cell behavior. To specifically target the functional properties of the 5 cadherin repeat domains (EC1-EC5) of T-cad, endothelial cells were transduced with lentivectors containing specific T-ca...

همزمان با ورود آفت غیر بومی و مهاجم شب پرة شمشاد Cydalima perspectalis به ایران گزارش آن از مناطق شمالی کشور، فعالیت­های پژوهشی در خصوص راهکارهای کنترل این قبل آلوده نمودن سایر شروع شد. همین راستا، پژوهش حاضر کارایی چند ترکیب حشره‌کش گروه ترکیبات بیولوژیک میکروبی، تنظیم کننده­های رشد گیاهی پره شرایط آزمایشگاهی صحرایی مورد بررسی قرار گرفت. نهایت بر اساس نتایج دست آمده، میان 12 حشره­کش بررسی، آفت...

Modulation of voltage-activated Ca channels by adenosine was investigated in male rat major pelvic ganglion (MPG) neurons by using the whole-cell variant of the patch-clamp technique. Adenosine inhibited high voltage-activated (HVA) Ca currents in a concentration-dependent manner with an EC50 of 313 nM and a maximal inhibition of 36%, respectively. Inhibition of HVA Ca currents in adrenergic an...

1 Department of Biostatistics, Groupe hospitalier Cochin Saint Vincent de Paul and University Paris 5 René 8 Descartes, 75014 Paris, France. 9 2 Department of Biochemistry and Molecular Biology, Molecular Endocrinology and Rare Diseases, CBPE, 10 Groupement hospitalier Lyon-Est, Hospices Civils de Lyon, 59 boulevard Pinel 69677 Bron, France 11 3 Association Française pour le Dépistage et la Pré...

The ability of a number of prostaglandin F2 (PGF2 ) analogs to mobilize intracellular Ca [Ca ]i and to compete for [H]PGF2 binding to prostaglandin F2 receptors (FP) was evaluated. Radioligand binding studies measuring displacement of [H]PGF2 by a variety of FP prostaglandin analogs yielded the following rank order of affinities: travoprost acid [( )-16-m-trifluorophenoxy tetranor PGF2 ; ( )-fl...

The tire wear transformation product 6PPD-quinone (6PPDQ) has been implicated as the causative factor for broad scale mortality events coho salmon in Pacific Northwest. Highly variable sensitivity to 6PPDQ closely related salmonids complicates efforts evaluate broader toxicological impacts aquatic ecosystems. Our goals were (1) validate large range of vivo species sensitivities reported coho, C...