Haemorrhagic fever viruses (HFVs) are a diverse group of viruses that cause a clinical disease associated with fever and bleeding disorder. HFVs that are associated with a potential biological threat are Ebola and Marburg viruses (Filoviridae), Lassa fever and New World arenaviruses (Machupo, Junin, Guanarito and Sabia viruses) (Arenaviridae), Rift Valley fever (Bunyaviridae) and yellow fever, ...

The Ebola virus was identified in 1976 during epidemics of haemorrhagic fever in southern Sudan and northern Zaire (now the Democratic Republic of the Congo). The average mortality rate of Ebola virus disease, formerly known as Ebola haemorrhagic fever, is around 50% with rates varying from 25-90% in past outbreaks. The chronology of the outbreaks of the disease in different countries since 197...

Ebola virus is named after the river in the former Zaire where a haemorrhagic fever initially identified in 1976 involved human to human transmission, as well as spread by contaminated injection equipments [1]. Ebola virus causes an acute febrile illness associated with a high mortality rate. The illness is characterized by multi-system involvement that begins with abrupt onset of headache, mya...

Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man, designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The recent west African outbreak of Ebolavirus has brought this filoviral infection again in limelight, Indian government has issued guidelines to various airports to screen travelers coming from Africa and middle east Haj...

Ebola haemorrhagic fever is a viral infection causing a major health problem worldwide. The rate of survival after infection is quite few. Therefore, the body’s immune system of one who get infection can potentially help prevent or reduce the likelihood of death from viral infections. Nutrition is an important concern in the patients who get the infection by the virus. This should be a populati...

BACKGROUND Infection with the Ebola virus induces overexpression of the procoagulant tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-factor pathway could ameliorate the effects of Ebola haemorrhagic fever. Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus. METHODS We used a rhesus macaque...