Objective(s): Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties.In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines.  This study assesses the effects of VPA on human papillomavirus E7 expression in HPV positive cell lines. Materials and Methods: Cell lines were treated by2 mmol/...

Background: E-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. Loss of the adhesive function of E-cadherin seems to promote invasive and metastatic properties of neoplastic cells. Objectives: The present study is a retrospective study aiming to evaluate the loss of E-cadher...

e-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (scce). the gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially scce. cpg islands’ methylation in the promoter region of e-cadherin is among the mechanisms that have been suggested for the e-cadherin silencing, howeve...

objective(s): valproic acid (vpa) has proven to be as one of the most promising useful drug with anticancer properties.in this study, we investigate the vpa effects on e-cadherin expression in hela, tc1, mkn45, and hct116 cell lines.  this study assesses the effects of vpa on human papillomavirus e7 expression in hpv positive cell lines. materials and methods: cell lines were treated by2 mmol/l...

objective: e-cadherin is a classic cadherin that plays a key role in epithelial cell adhesion. this protein is being referred to as the suppressor of proliferation and invasion. limited studies have investigated e-cadherin expression in salivary gland neoplasms. this study sought to assess the expression of e-cadherin and its possible role in progression and invasion of salivary gland neoplasms...

E-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (SCCE). The gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially SCCE. CpG islands’ methylation in the promoter region of E-cadherin is among the mechanisms that have been suggested for the E-cadherin silencing, howeve...

background : mdm2, e-cadherin, survivin and her2 genes are involved in the regulation of normal cell growth. however, any crucial change in their expression levels can convert a normal cell into a cancer cell. numerous studies have identified alterations of these gene expression levels in various cancers, particularly in breast cancer. thus, they may be used as diagnostic biomarkers. in this ex...

objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...

Objectives: E-cadherin is a transmembrane glycoprotein, which is responsible for cell adhesion and its expression decreases in dysplastic lesions. This study aimed to assess the expression of this marker in oral lichen planus (OLP) with and without dysplasia to assess its potential for use as a predictor of malignant transformation. Methods: This descriptive, cross-sectional study w...